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Safety · Contraindications

Absolute versus relative contraindications

HN
h.nwosuTL221 Oct 2025#1

On the subject in the title: Absolute versus relative contraindications Working notes rather than a conclusion.

Proposing that absolute versus relative contraindications deserves a maintained page rather than a recurring topic, and drafting the skeleton here so that the argument about scope happens before the writing rather than after.

What I think belongs on it, what does not, and the three claims that would need a citation each.

9 likes 9mo
BR
buffer_reviewTL3Regular29 Oct 2025#2

The section of the product information covering special warnings is usually longer and more useful than the contraindications list itself.

I am reporting what happened, not recommending it.

13 likes 9mo
MA
mi.amankwahTL24 Nov 2025#3

Post #2 is right about the mechanism and I think understates the practical bit.

History of pancreatitis: these compounds can rarely trigger pancreatitis. History of pancreatitis increases relative risk. That is a relative contraindication, not absolute, but requires monitoring.

27 likes 9mo
L
LJankowiakTL3Regular9 Nov 2025#4
h.nwosu, post #1: On the subject in the title: Absolute versus relative contraindications Working notes rather than a conclusion. Proposing that absolute versus relative contraindications deserves a maintained page rather than a recurring topic, and drafting the skeleton here so that the argument about scope happens before the writing rather than after.… Go to post

No disagreement from me. Posting only so the question does not look ignored.

0 likes in reply to #1 9mo
FN
f.novakTL214 Nov 2025#5

Concurrent insulin or sulfonylureas: not an absolute contraindication but requires dose adjustment and close monitoring for hypoglycemia. The combination is used with caution, not avoided.

That matches what I was told, which is not the same as knowing it.

8 likes 8mo
K
KTurkingtonTL3Regular19 Nov 2025#6

Gastroparesis or severe delayed gastric emptying: these compounds slow gastric emptying. Pre-existing severe gastroparesis can be worsened. That is a relative contraindication depending on baseline severity.

Not the whole picture, but the part of it I can speak to.

19 likes 8mo
AN
a.norgaardTL223 Nov 2025 · edited#7
KTurkington, post #6: Gastroparesis or severe delayed gastric emptying: these compounds slow gastric emptying. Pre-existing severe gastroparesis can be worsened. That is a relative contraindication depending on baseline severity. Not the whole picture, but the part of it I can speak to. Go to post

Agreed on all of that, and I have nothing to add to it.

0 likes in reply to #6 8mo
TI
trough_indexTL3Regular27 Nov 2025#8
h.nwosu, post #1: On the subject in the title: Absolute versus relative contraindications Working notes rather than a conclusion. Proposing that absolute versus relative contraindications deserves a maintained page rather than a recurring topic, and drafting the skeleton here so that the argument about scope happens before the writing rather than after.… Go to post

On post #5 — agreed on the reasoning, with one qualification.

Reading the contraindications section of the actual product information takes two minutes and answers most questions asked here.

0 likes in reply to #1 8mo
CN
c.nybergTL22 Dec 2025#9
Moved from Adverse events by KLindqvist. Category placement is not obvious from outside and getting it wrong is expected. This topic will get better answers here. The move is recorded in the public log citing R7.

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