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1,535 topics · page 1 of 52

Topic	Participants	Replies	Views	Activity
Journal club: LEADER as the historical anchor Evidence › Journal club estimand number needed to treat journal club effect size Pinned Journal club: LEADER as the historical anchor Writing it up because I had to work it out twice and would rather nobody else did. Comparing STEP 1 ( N Engl J Med , 2021) with SURMOUNT-4 ( JAMA , 2024) and…	+103	110	8.1k	2h
About the Announcements category Meta › Announcements guidelines trust levels moderation Pinned Wiki Staff announcements, policy changes, and scheduled maintenance. Read-only except for questions. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with…	+3	7	8.7k	4h
About the Mass spectrometry category Analytics › Mass spectrometry LC-MS high-resolution MS mass error (ppm) Pinned Wiki LC-MS and high-resolution MS, charge states, mass accuracy in ppm, and what identity confirmation does and does not establish. This post is a community wiki: any member at trust level 3 or above can edit it,…	+5	9	19k	6h
What I would want from a home test that does not exist yet Analytics › Home & field testing ELISA documentation quality LOD & LOQ Solved Pinned The question in the title: What I would want from a home test that does not exist yet I will give what I have already checked below so nobody repeats it. A documentation question rather than an analytical…	+46	50	8k	6h
About the Comorbidities category Clinical › Comorbidities type 2 diabetes chronic kidney disease MASH / hepatic steatosis Pinned Wiki Type 2 diabetes, hepatic steatosis, sleep apnoea, cardiovascular and renal disease. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author…		4	16k	12h
About the N-of-1 designs category Research Methods › N-of-1 designs worked example confounding effect size Pinned Wiki Designing a personal experiment that could actually change your mind, including washouts and blinding. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…		4	22k	14h
Private prescribing in the UK: what is actually involved Regional › UK & Ireland personal import cost per milligram MHRA Pinned On the subject in the title: Private prescribing in the UK: what is actually involved Working notes rather than a conclusion. A coverage question with the paperwork detail included, since that is what…	+66	76	46k	14h
About the Impurities & related substances category Analytics › Impurities & related substances forced degradation counter-ion content water content Pinned Wiki Deletion sequences, oxidation, deamidation, aggregates, residual solvents, and counter-ion content. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…	+6	10	50k	15h
About the Reconstitution category Practice › Reconstitution reconstitution concentration maths syringe units Pinned Wiki Diluent choice, volumes, resulting concentrations, worked examples, and the errors we see most often. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…	+1	5	15k	16h
About the HPLC & UHPLC category Analytics › HPLC & UHPLC HPLC peak integration gradient method Pinned Wiki Reversed-phase separations, gradients, columns, integration, and reading a chromatogram properly. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…		4	137	18h
About the Hydration & electrolytes category Nutrition & Training › Hydration & electrolytes fatigue blood pressure heart rate Pinned Wiki Fluid intake, sodium, potassium and magnesium, and the very ordinary causes of week-two malaise. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…		4	3.6k	18h
About the Independent verification category Sourcing › Independent verification Janoshik Analytical Medutest PeptideMeter Pinned Wiki Janoshik, Medutest, PeptideMeter and VendorInvestigate results, how to submit a sample, and how to read what comes back. This post is a community wiki: any member at trust level 3 or above can edit it, and…	+1	5	5.8k	23h
MS/MS sequence confirmation: what it costs and when it is worth it Analytics › Mass spectrometry LC-MS MALDI-TOF charge states Solved Pinned MS/MS sequence confirmation: what it costs and when it is worth it — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it…	+2	6	2.7k	1d
Packaging that arrived damaged: documenting it properly Sourcing › Logistics shipping customs temperature excursion cold chain Pinned Packaging that arrived damaged: documenting it properly Writing it up because I had to work it out twice and would rather nobody else did. A logistics question, since the answers here are usually better than…	+43	49	26k	1d
Insomnia at a dose step: reported experiences — the long version Wellbeing › Sleep obstructive sleep apnoea heart rate fatigue Solved Pinned Insomnia at a dose step: reported experiences — the long version Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The…	+47	51	31k	1d
About the Shortages category Access › Shortages shortage compounding FDA Pinned Wiki Supply interruptions, official shortage notices, and managing an unplanned gap. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and…	+3	7	9.9k	1d
Angle of injection and whether 90 degrees is always right — the long version Practice › Administration injection site reaction needle gauge & length injection site rotation missed dose Pinned Angle of injection and whether 90 degrees is always right — the long version Writing it up because I had to work it out twice and would rather nobody else did. Reporting something rather than asking about it,…	+50	55	15k	2d
Second pass at: When your prescriber and the evidence disagree Clinical › Prescriber conversations beginner friendly type 2 diabetes telehealth prior authorisation Pinned Second pass at: When your prescriber and the evidence disagree — setting out what I have, and where I think it stops being reliable. General question, not a request for advice about my own care — I know the…	+51	55	9.2k	2d
About the Adverse events category Safety › Adverse events pancreatitis vomiting gallbladder Pinned Wiki Serious and unexpected events, how to document them, and where to report them officially. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…	+2	6	8.7k	2d
About the Resistance training category Nutrition & Training › Resistance training lean mass loss fatigue DXA Pinned Wiki Programming while losing weight quickly, realistic expectations, and recovery. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a…		4	40k	17d
About the Oral incretins category Compounds › Oral incretins oral semaglutide orforglipron PIONEER programme Pinned Wiki Oral semaglutide, orforglipron and the absorption problem. PIONEER and OASIS data. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author…		4	6.2k	20d
About the Receptor biology category Pharmacology › Receptor biology amylin analogues semaglutide tirzepatide Pinned Wiki GLP-1, GIP, glucagon and amylin receptor signalling, bias, desensitisation and central versus peripheral action. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit…	+6	10	34k	20d
About the Welcome category Start Here › Welcome onboarding guidelines beginner friendly Pinned Wiki Introductions, orientation, and the pinned reading list for new members. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a note.…	+4	8	11k	27d
About the Syringes & needles category Devices › Syringes & needles syringe units dead volume needle gauge & length Pinned Wiki Insulin syringe graduations, dead volume, gauge and length selection, and reading units correctly. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…		4	45k	1mo
About the COA interpretation category Analytics › COA interpretation certificate of analysis documentation quality batch & lot numbers Pinned Wiki What a certificate of analysis commits its issuer to, which fields matter, and how to spot one that says almost nothing. This post is a community wiki: any member at trust level 3 or above can edit it, and…	+8	12	8.5k	2mo
About the Interactions category Practice › Interactions insulin metformin hypoglycaemia Pinned Wiki Drug, supplement and food interactions — separating timing inconveniences from clinically important ones. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…	+4	8	1.9k	2mo
EU-wide position versus national implementation — what changed since Regional › European Union EMA cost per milligram personal import formulary Pinned EU-wide position versus national implementation — what changed since Writing it up because I had to work it out twice and would rather nobody else did. A coverage question with the paperwork detail included,…	+22	26	58k	2mo
About the Preprints category Evidence › Preprints preprint risk of bias needs a source Pinned Wiki Unrefereed work, clearly labelled as such, with the usual caveats stated once and taken seriously. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…	+3	7	14k	3mo
About the Insurance & coverage category Access › Insurance & coverage insurance prior authorisation appeals Pinned Wiki Prior authorisation, appeals, denial letters, and documentation that helps. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a…	+2	6	3.2k	3mo
Adolescents: a distinct evidence base — one year on Clinical › Special populations bariatric surgery history disordered eating pregnancy & planning adolescents Pinned Wiki Posting this under the heading it deserves: Adolescents: a distinct evidence base — one year on Everything below is what sits behind that. General question, not a request for advice about my own care — I know…	+78	88	9.3k	3mo

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