Ranked by engagement

Top topics — this month

The default Top view covers the last month. Period variants are linked below.

This week This month This quarter This year All time

374 topics

Topic	Participants	Replies	Views	Activity
Second pass at: Metformin co-administration and additive GI effects Practice › Interactions hypoglycaemia delayed gastric emptying metformin needs a source On the subject in the title: Second pass at: Metformin co-administration and additive GI effects Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am…	+131	142	56k	19d
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Evidence › Journal club estimand risk of bias number needed to treat Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SUSTAIN 6 ( N Engl…	+108	122	52k	7d
[2026 update] Regional warehouse stock versus direct despatch Sourcing › Logistics packaging customs shipping cold chain Regional warehouse stock versus direct despatch Writing it up because I had to work it out twice and would rather nobody else did. A logistics question, since the answers here are usually better than anywhere…	+135	147	32k	2d
[2026 update] Interpreting a result that disagrees with the supplier's certificate Sourcing › Independent verification Medutest VendorInvestigate blind sampling third-party testing Solved On the subject in the title: Interpreting a result that disagrees with the supplier's certificate Working notes rather than a conclusion. Structured report rather than an opinion, following the format the…	+121	128	51k	17h
What consumer-accessible tests can and cannot determine — a second dataset Analytics › Home & field testing ELISA LOD & LOQ third-party testing documentation quality Solved What consumer-accessible tests can and cannot determine — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know…	+117	131	45k	10h
Seven-day rolling means and why weekly readings mislead Outcomes › Progress reports data table DXA effect size long read Seven-day rolling means and why weekly readings mislead Writing it up because I had to work it out twice and would rather nobody else did. Maintenance rather than loss, which is the part of this that almost…	+109	125	42k	10h
Micro-titration: a disputed topic, argued properly Practice › Dosing & titration titration dose reduction worked example tirzepatide Solved Wiki Micro-titration: a disputed topic, argued properly Writing it up because I had to work it out twice and would rather nobody else did. A question about technique rather than about dose. I have been doing the…	+99	110	61k	2d
Revisiting: The report format the maintainers ask for, and why each field is there Sourcing › Vendor reports batch & lot numbers Janoshik Analytical documentation quality third-party testing Posting this under the heading it deserves: Revisiting: The report format the maintainers ask for, and why each field is there Everything below is what sits behind that. Structured report rather than an…	+100	108	57k	1d
Alcohol: what is documented and what is folklore Practice › Interactions metformin insulin delayed gastric emptying Posting this under the heading it deserves: Alcohol: what is documented and what is folklore Everything below is what sits behind that. A question about technique rather than about dose. I have been doing the…	+120	134	11k	2d
Tracking a shortage from primary sources rather than rumour Access › Shortages shortage FDA formulary Tracking a shortage from primary sources rather than rumour — setting out what I have, and where I think it stops being reliable. Documenting an access outcome, dated, because everything in this category…	+121	126	35k	13h
A 5 mg vial and a 0.25 mg dose: the arithmetic in full Practice › Reconstitution syringe units worked example reconstitution bacteriostatic water Solved A 5 mg vial and a 0.25 mg dose: the arithmetic in full Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+124	141	16k	2d
Insurance and replacement policies, compared Sourcing › Logistics temperature excursion cold chain customs shipping Solved On the subject in the title: Insurance and replacement policies, compared Working notes rather than a conclusion. Structured report rather than an opinion, following the format the maintainers asked for.…	+115	122	17k	17h
Journal club: orforglipron phase 2 and the non-peptide question Evidence › Journal club journal club estimand randomised trial Journal club: orforglipron phase 2 and the non-peptide question Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in support…	+120	132	13k	1d
Reading a home test result without over-claiming Analytics › Home & field testing ELISA documentation quality LOD & LOQ third-party testing Reading a home test result without over-claiming — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it checked. retatrutide has a…	+124	137	19k	7h
Follow-up: Search filters: what is missing Meta › Site feedback guidelines site feedback moderation On the subject in the title: Search filters: what is missing Working notes rather than a conclusion. Nominating something for promotion into the documentation commons. The topic in question keeps being…	+126	141	1.6k	29d
What a certificate commits its issuer to Analytics › COA interpretation reference standards batch & lot numbers amino acid analysis The question in the title: What a certificate commits its issuer to I will give what I have already checked below so nobody repeats it. A documentation question rather than an analytical one. I have a…	+101	116	26k	19h
Carryover and the ghost peak from last week's standard — what changed since Analytics › HPLC & UHPLC gradient method data table HPLC UV & DAD detection Solved Carryover and the ghost peak from last week's standard — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the…	+98	114	37k	22d
Journal club: SUSTAIN 6 and its retinopathy signal Evidence › Journal club estimand effect size risk of bias journal club Under review On the subject in the title: Journal club: SUSTAIN 6 and its retinopathy signal Working notes rather than a conclusion. I have seen SELECT ( N Engl J Med , 2023) cited in support of a claim I do not think it…	+110	122	46k	1d
Why we ask for units every single time, with three examples of what goes wrong Start Here › How to Ask worked example onboarding beginner friendly guidelines Why we ask for units every single time, with three examples of what goes wrong — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below,…	+118	135	2.2k	11d
Journal club: what we got wrong in an earlier session Evidence › Journal club number needed to treat effect size randomised trial journal club On the subject in the title: Journal club: what we got wrong in an earlier session Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read it before posting; the…	+114	125	2.5k	23h
Coming back to: Why a preprint's supplementary material is often the best part Evidence › Preprints risk of bias effect size preprint Under review Why a preprint's supplementary material is often the best part — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SURPASS-2 ( N Engl J Med , 2021) with STEP 4 (…	+109	116	36k	2d
Revisiting: The best-written scientific paper you have read Lounge › Off topic beginner friendly long read Posting this under the heading it deserves: Revisiting: The best-written scientific paper you have read Everything below is what sits behind that. Lower-stakes topic, but the sourcing rule still applies if…	+102	121	21k	1h
Request: a per-category review queue Meta › Feature requests site feedback translation wiki post Request: a per-category review queue Writing it up because I had to work it out twice and would rather nobody else did. Nominating something for promotion into the documentation commons. The topic in question…	+125	136	13k	2h
What is genuinely unknown about long-term amylin agonism Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide cagrisema amylin analogues Solved What is genuinely unknown about long-term amylin agonism — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing STEP 8 ( JAMA , 2022) with SURMOUNT-1 ( N Engl J Med…	+83	91	46k	1d
Spreadsheets: an appreciation — what changed since Lounge › Off topic long read beginner friendly Spreadsheets: an appreciation — what changed since — setting out what I have, and where I think it stops being reliable. Lower-stakes topic, but the sourcing rule still applies if anyone makes a claim.…	+102	113	26k	17h
Submitting a sample: the process end to end Sourcing › Independent verification blind sampling PeptideMeter VendorInvestigate third-party testing On the subject in the title: Submitting a sample: the process end to end Working notes rather than a conclusion. I would like to talk about documentation quality as a signal, separately from product quality.…	+99	114	29k	21h
I joined for one answer and stayed for a year — what changed my mind Start Here › Welcome guidelines onboarding trust levels Posting this under the heading it deserves: I joined for one answer and stayed for a year — what changed my mind Everything below is what sits behind that. Question in the title. Context below, and I have…	+96	114	17k	just now
Trust level 3 requirements: a clarification — does this still hold? Meta › Announcements trust levels moderation site feedback guidelines Solved Asking directly, because I could not find a straight answer: Trust level 3 requirements: a clarification — does this still hold? Process question about how this site works. I have read the guidelines and the…	+76	90	57k	9h
Coming back to: Time to steady state after a dose increase Pharmacology › Pharmacokinetics semaglutide missed dose liraglutide worked example Time to steady state after a dose increase Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the first three replies will…	+104	110	16k	2d
Pooling trials with different estimands Evidence › Meta-analyses publication bias risk of bias effect size meta-analysis Solved On the subject in the title: Pooling trials with different estimands Working notes rather than a conclusion. Comparing SELECT ( N Engl J Med , 2023) with SURMOUNT-1 ( N Engl J Med , 2022) and finding the…	+120	132	2.3k	1d

Sponsored Sigma-Aldrich — certified reference materialsReference standards, analytical reagents and certified materials for method calibration. If you are validating a method, this is where the standard comes from.Reference standards →