Why plausible mechanism is not evidence of effect: a mechanism that is chemically or biologically plausible can fail in practice for dozens of reasons — bioavailability, off-target effects, metabolism, clearance, or simply that the mechanism does not do what the theory predicts in a living system. Plausibility is necessary for hope but not sufficient for evidence.
Analytical identity of BPC-157: a 15-mer with a simple mass — does this still hold? posts 31–34
This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.
post #31 is right about the mechanism and I think understates the practical bit.
What would change the position on repair peptides: adequately powered, published, peer-reviewed randomised controlled human trials with pre-specified outcomes. That is the standard applied to every other therapeutic claim on this site and it is the standard applied here.
Collapsed as off-topic by two members at trust level 3 or above
I read post #31 twice before replying, because I had assumed the opposite.
Why plausible mechanism is not evidence of effect: a mechanism that is chemically or biologically plausible can fail in practice for dozens of reasons — bioavailability, off-target effects, metabolism, clearance, or simply that the mechanism does not do what the theory predicts in a living system. Plausibility is necessary for hope but not sufficient for evidence.
Analytical identity of BPC-157: a 15-residue peptide with an unambiguous mass (≈1419.5 Da). Identity confirmation by LC-MS is trivially easy, which means there is no excuse for an unverified identity on this compound.
This topic was referenced in
- Stability of BPC-157 in solution: what has been measured — one year onCompounds › Repair & healing peptides · 98 replies
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