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Compounds · Repair & healing peptides · continued

Analytical identity of BPC-157: a 15-mer with a simple mass — does this still hold? posts 31–34

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

MY
m.yilmazTL2 Moderator13 Jun 2026#31

Why plausible mechanism is not evidence of effect: a mechanism that is chemically or biologically plausible can fail in practice for dozens of reasons — bioavailability, off-target effects, metabolism, clearance, or simply that the mechanism does not do what the theory predicts in a living system. Plausibility is necessary for hope but not sufficient for evidence.

0 likes 1mo
AS
a.salcedoTL3Regular17 Jun 2026#32

post #31 is right about the mechanism and I think understates the practical bit.

What would change the position on repair peptides: adequately powered, published, peer-reviewed randomised controlled human trials with pre-specified outcomes. That is the standard applied to every other therapeutic claim on this site and it is the standard applied here.

25 likes 1mo
SC
s.cardosoTL222 Jun 2026#33
GI
g.ibarraTL2 Moderator27 Jun 2026#34
endpoint_line, post #22: The absence of adequately powered published randomised human trials is the central fact about BPC-157. This site states that plainly rather than hedging. Mechanistic plausibility does not substitute for it. Go to post

Analytical identity of BPC-157: a 15-residue peptide with an unambiguous mass (≈1419.5 Da). Identity confirmation by LC-MS is trivially easy, which means there is no excuse for an unverified identity on this compound.

1 like in reply to #22 1mo

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