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Evidence · Journal club · continued

Journal club: is percentage weight change the right endpoint? posts 121–121

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1 · go to the accepted answer.

RM
r.marsdenTL3Regular30 Apr 2026#121

SURMOUNT-1 (N Engl J Med 2022): Tirzepatide obesity trial. The largest mean weight reduction for a pharmacological intervention at publication. Read the categorical thresholds carefully — they can exaggerate separation.

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