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Clinical · Special populations

Older adults, sarcopenia risk, and the trade-off nobody quantifies — does this still hold?

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Solved by baseline_peak in post #2
Coming back to the opening post, because the follow-up matters more than the original answer. Adolescents: a distinct evidence base exists. The compounds are not approved for routine adolescent obesity but are being studied. Adolescent physiology and psychology differ from adults' in ways that matter for this…

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endo_fellow_rkTL3Endocrinology fellow16 Jul 2025#1

Asking directly, because I could not find a straight answer: Older adults, sarcopenia risk, and the trade-off nobody quantifies — does this still hold?

General question, not a request for advice about my own care — I know the difference and I would rather be told to see my prescriber than get an answer that pretends otherwise.

I have a panel in front of me with one value outside the reference interval and everything else within it. My instinct is that a single out-of-range result on a single draw is close to uninformative, and I would like to understand how the people who read these professionally think about that.

What I am actually asking is how to tell an interesting result from an uninteresting one before booking an appointment about it.

18 likes 12mo
BP
baseline_peakTL2Member Solution7 Aug 2025#2

Coming back to the opening post, because the follow-up matters more than the original answer.

Adolescents: a distinct evidence base exists. The compounds are not approved for routine adolescent obesity but are being studied. Adolescent physiology and psychology differ from adults' in ways that matter for this medication class.

22 likes 12mo
WM
w.moreauTL2 Moderator22 Aug 2025#3
baseline_peak, post #2: Coming back to the opening post, because the follow-up matters more than the original answer. Adolescents: a distinct evidence base exists. The compounds are not approved for routine adolescent obesity but are being studied. Adolescent physiology and psychology differ from adults' in ways that matter for this medication class. Go to post

Renal impairment: the compounds are cleared renally to some degree. Dose adjustments might be needed in severe renal impairment. Consulting with a clinician familiar with renal dosing is prudent.

0 likes in reply to #2 11mo

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