Compounds · Secretagogues & GH axis

What a well-designed human trial of a secretagogue would look like

Compounds › Secretagogues & GH axis GHRP class ipamorelin CJC-1295 tesamorelin observational data

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Solved by n.ramos in post #3

IGF-1 as a surrogate: it is a better integrated measure than a spot growth hormone level and it is still a surrogate, with all the caveats that come with surrogates. Stable or rising IGF-1 is not the same as "this is working" in any health-related sense.

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h.oyelowoTL2Regular30 Aug 2024#1

What a well-designed human trial of a secretagogue would look like I have a specific reason for asking rather than idle curiosity, and the context is below.

I have seen SUSTAIN 6 (N Engl J Med, 2016) cited in support of a claim I do not think it supports, twice this month, so I would like to work through what it actually shows.

My reading is that the trial is sound for its own question and is being stretched to answer a different one. I might be wrong about that, which is why this is a topic rather than a correction.

What I would like from this discussion: someone who disagrees with me to say why, with the section of the paper they are relying on.

13 likes 23mo

RodriguesTL3Regular20 Nov 2024#2

the opening post is right about the mechanism and I think understates the practical bit.

GHRH analogues versus ghrelin mimetics are often conflated but they are different mechanisms. GHRH analogues (like CJC-1295) cause the pituitary to release growth hormone. Ghrelin mimetics (like GHRPs) act on the ghrelin receptor directly. The effect on growth hormone secretion is similar but the mechanisms are distinct.

1 like 20mo

n.ramosTL2 Moderator Solution17 Jan 2025#3

Rodrigues, post #2: the opening post is right about the mechanism and I think understates the practical bit. GHRH analogues versus ghrelin mimetics are often conflated but they are different mechanisms. GHRH analogues (like CJC-1295) cause the pituitary to release growth hormone. Ghrelin mimetics (like GHRPs) act on the ghrelin receptor directly. The… Go to post

IGF-1 as a surrogate: it is a better integrated measure than a spot growth hormone level and it is still a surrogate, with all the caveats that come with surrogates. Stable or rising IGF-1 is not the same as "this is working" in any health-related sense.

7 likes in reply to #2 18mo

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