Intersection · Compounds × effect size

Compounds topics tagged effect size

Topics in Compounds carrying the tag effect size. Magnitude, not just direction or significance.

89 topics

Topic	Participants	Replies	Views	Activity
What TRIUMPH is designed to answer, and why we should not pre-empt it — does this still hold? randomised trial effect size TRIUMPH programme retatrutide Solved Asking directly, because I could not find a straight answer: What TRIUMPH is designed to answer, and why we should not pre-empt it — does this still hold? An honest uncertainty about TRIUMPH rather than a…	+43	47	5.5k	just now
What TRIUMPH is designed to answer, and why we should not pre-empt it retatrutide effect size TRIUMPH programme preprint Solved What TRIUMPH is designed to answer, and why we should not pre-empt it I have a specific reason for asking rather than idle curiosity, and the context is below. TRIUMPH keeps being re-asked here and I think…	+4	8	142	6h
SURPASS-2 and the comparator dose question that will not go away — what changed since SURMOUNT programme tirzepatide effect size Posting this under the heading it deserves: SURPASS-2 and the comparator dose question that will not go away — what changed since Everything below is what sits behind that. What changes if the standard…	+2	6	5.5k	7h
Molecular mass of semaglutide and why the figure differs between sources SELECT trial effect size semaglutide STEP programme Molecular mass of semaglutide and why the figure differs between sources — setting out what I have, and where I think it stops being reliable. Putting the numbers in the first post, because a question about a…	+101	110	12k	16h
Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry retatrutide randomised trial effect size preprint Solved Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Writing it up because I had to work it out twice and would rather nobody else did. A methods question rather than a substantive…	+10	14	8.4k	16h
What the GIP component of tirzepatide is thought to contribute, and how confident we can be tirzepatide SURPASS programme SURMOUNT programme effect size Solved What the GIP component of tirzepatide is thought to contribute, and how confident we can be I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to know what…	+16	20	23k	19h
Why retatrutide discussion here is more cautious than elsewhere — one year on TRIUMPH programme effect size preprint retatrutide Asking directly, because I could not find a straight answer: Why retatrutide discussion here is more cautious than elsewhere — one year on Two things I would like separated before anyone answers on…	+92	97	3.6k	20h
Retatrutide mass and identity: what a report should show TRIUMPH programme preprint retatrutide effect size Solved Posting this under the heading it deserves: Retatrutide mass and identity: what a report should show Everything below is what sits behind that. The question about retatrutide mass and identity that I actually…	+22	27	872	22h
Why cagrilintide alone is discussed so much less than in combination — does this still hold? cagrisema randomised trial cagrilintide effect size Solved Under review Why cagrilintide alone is discussed so much less than in combination — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Cagrilintide alone:…	+27	31	1.2k	22h
Tracking semaglutide's approved indications across jurisdictions, dated semaglutide effect size SELECT trial Tracking semaglutide's approved indications across jurisdictions, dated Writing it up because I had to work it out twice and would rather nobody else did. Putting the numbers in the first post, because a…	+15	19	2.8k	1d
Historical amylin analogues and what happened to them randomised trial cagrilintide cagrisema effect size Posting this under the heading it deserves: Historical amylin analogues and what happened to them Everything below is what sits behind that. Proposing that historical amylin analogues deserves a maintained…	+29	36	31k	1d
What is genuinely unknown about long-term amylin agonism randomised trial cagrilintide cagrisema amylin analogues Solved What is genuinely unknown about long-term amylin agonism — that is the question, and I have not found it answered plainly anywhere I have looked. A comparison question rather than a question about one…	+83	91	46k	1d
Follow-up: The retatrutide phase 2 obesity paper, read closely retatrutide randomised trial preprint effect size The retatrutide phase 2 obesity paper, read closely — setting out what I have, and where I think it stops being reliable. A follow-up question about retatrutide phase 2 obesity paper that I did not know to…	+19	23	16k	2d
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction retatrutide preprint randomised trial effect size Solved The question in the title: Why a glucagon receptor agonist in a weight-loss compound is not a contradiction I will give what I have already checked below so nobody repeats it. I would like to disagree…	+43	47	19k	2d
Tirzepatide storage and stability: what is published versus what is assumed SURPASS programme randomised trial SURMOUNT programme effect size On the subject in the title: Tirzepatide storage and stability: what is published versus what is assumed Working notes rather than a conclusion. Asking about tirzepatide storage and stability directly,…	+17	21	17k	12d
Second pass at: Cagrilintide molecular characteristics and analytical considerations amylin analogues effect size cagrisema On the subject in the title: Second pass at: Cagrilintide molecular characteristics and analytical considerations Working notes rather than a conclusion. Something about Cagrilintide molecular characteristics…		4	5k	21d
Is "synergy" the right word for the combination data? randomised trial cagrilintide effect size Is "synergy" the right word for the combination data? — that is the question, and I have not found it answered plainly anywhere I have looked. Setting out what I think I know about this compound and asking…	+5	9	13k	25d
Coming back to: What the published dose-response for semaglutide actually looks like above 2.4 mg effect size type 2 diabetes semaglutide STEP programme Solved The question in the title: What the published dose-response for semaglutide actually looks like above 2.4 mg I will give what I have already checked below so nobody repeats it. I would like to know what…	+23	27	9.9k	1mo
Follow-up: Tirzepatide and nausea: is the profile genuinely different or just differently reported? tirzepatide SURMOUNT programme effect size randomised trial Solved Tirzepatide and nausea: is the profile genuinely different or just differently reported? I have a specific reason for asking rather than idle curiosity, and the context is below. Something about Tirzepatide…	+109	122	3.6k	2mo
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction — one year on preprint retatrutide TRIUMPH programme randomised trial Why a glucagon receptor agonist in a weight-loss compound is not a contradiction — one year on — that is the question, and I have not found it answered plainly anywhere I have looked. The question about…	+3	7	1k	2mo
Comparing the STEP programme populations: who was actually enrolled SELECT trial STEP programme semaglutide effect size Solved Comparing the STEP programme populations: who was actually enrolled Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before anyone answers…		2	7.5k	2mo
Is there a ceiling dose beyond which semaglutide stops adding benefit? effect size type 2 diabetes SELECT trial Is there a ceiling dose beyond which semaglutide stops adding benefit? I have a specific reason for asking rather than idle curiosity, and the context is below. Putting the numbers in the first post, because…		2	14k	2mo
The 2.5 mg starting dose is not a therapeutic dose — why that matters SURPASS programme SURMOUNT programme effect size Solved The 2.5 mg starting dose is not a therapeutic dose — why that matters Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about 2.5 mg starting dose that I…	+119	136	5.6k	2mo
Why retatrutide discussion here is more cautious than elsewhere randomised trial effect size retatrutide preprint Solved Why retatrutide discussion here is more cautious than elsewhere I have a specific reason for asking rather than idle curiosity, and the context is below. A question about retatrutide discussion that I think…	+7	12	7.7k	2mo
What the published dose-response for semaglutide actually looks like above 2.4 mg STEP programme type 2 diabetes effect size SELECT trial Solved What the published dose-response for semaglutide actually looks like above 2.4 mg — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to know what people here…		2	10k	3mo
Coming back to: Semaglutide in people without diabetes: what the evidence base looks like effect size randomised trial SELECT trial On the subject in the title: Semaglutide in people without diabetes: what the evidence base looks like Working notes rather than a conclusion. Two things I would like separated before anyone answers on…	+41	46	1.2k	4mo
Why semaglutide solutions can look faintly opalescent and when that matters semaglutide SELECT trial randomised trial effect size Solved The question in the title: Why semaglutide solutions can look faintly opalescent and when that matters I will give what I have already checked below so nobody repeats it. A follow-up question about…	+73	79	2k	4mo
Semaglutide half-life: where the 165 to 184 hour figure comes from semaglutide effect size randomised trial type 2 diabetes Wiki Semaglutide half-life: where the 165 to 184 hour figure comes from — setting out what I have, and where I think it stops being reliable. Putting the numbers in the first post, because a question about a…	+128	145	3k	4mo
The most common factual error about semaglutide on the internet — what changed since effect size randomised trial SELECT trial type 2 diabetes The most common factual error about semaglutide on the internet — what changed since — setting out what I have, and where I think it stops being reliable. Putting the numbers in the first post, because a…	+42	46	1.7k	5mo
[2026 update] Amylin and gastric emptying: overlapping mechanisms with incretins amylin analogues randomised trial effect size cagrisema Amylin and gastric emptying: overlapping mechanisms with incretins — setting out what I have, and where I think it stops being reliable. A question about Amylin and gastric emptying that I think has a…	+21	25	44k	5mo

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