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Compounds · Semaglutide

Is there a ceiling dose beyond which semaglutide stops adding benefit?

NH
n.hartmannTL228 Jan 2026#1

Is there a ceiling dose beyond which semaglutide stops adding benefit? I have a specific reason for asking rather than idle curiosity, and the context is below.

Putting the numbers in the first post, because a question about a compound without them turns into a question about somebody's impression of it.

semaglutide, monoisotopic mass near 4113.6 Da, 14 weeks of my own notes, and 7 lots from 2 suppliers with a purity figure on each. That is the whole basis of what follows.

What I want checked is the reasoning I have built on top of it, not the figures themselves.

43 likes 6mo
AV
a.villalobosTL27 Apr 2026#2

The oral formulation is a genuinely different pharmaceutical problem from the injectable and shares only the active molecule. Absorption enhancers, fasting requirements and a very different bioavailability mean dose numbers do not translate between the two at all.

11 likes 4mo
BT
baseline_tableTL2Member26 May 2026#3

On dose steps: the four-week interval in the pivotal programme was a trial design choice, and slower escalation was not studied. That means the evidence supports not going faster and says nothing at all about going slower.

I would be glad to be shown a cleaner way of putting this.

1 like 2mo

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