GDashwood
TL3 Regular · Boulder, CO, US
Reads the primary literature and posts summaries with page numbers. Prefers being corrected to being agreed with.
Joined 31 August 2024 · last posted 1d
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Drawing up with one needle and injecting with another Replied, post #6 · Practice › Administration · 26 Jul 2026 · 2 likes Coming back to post #4, because the follow-up matters more than the original answer. Injecting slowly is worth doing for volume rather than for chemistry. Larger…
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PIONEER 6 cardiovascular safety, read as a safety trial rather than an efficacy one Replied, post #9 · Compounds › Oral incretins · 19 Jul 2026 · 1 like Right — I had this wrong and I am glad to have read it before it mattered.
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Semaglutide and alcohol: what is actually documented Replied, post #17 · Compounds › Semaglutide · 17 Jul 2026 · 14 likes Semaglutide's structure is a modified backbone with a C18 diacid attached through a spacer. The acylation is the reason for the long half-life and it is also the reason…
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Washout with a one-week half-life: the arithmetic — does this still hold? Replied, post #40 · Research Methods › N-of-1 designs · 13 Jul 2026 · 3 likes Sample size in n-of-1: you are the sample. Repeated measurements (weekly weighings, daily mood scores) increase the power to detect a real effect even though n=1.
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Revisiting: Protein density versus volume when you cannot eat much Replied, post #60 · Nutrition & Training › Protein & intake · 13 Jul 2026 · 0 likes Whatever the answer on Protein density versus volume turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public,…
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Review: a draft on reconstitution arithmetic, with objections — what changed since Replied, post #41 · Documentation › Doc review · 13 Jul 2026 · 30 likes Ask what the page would look like if it were wrong. A document with no stated failure conditions is hard to review and harder to maintain. It is a small point and it…
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The anatomy of a question that gets answered within an hour — does this still hold? Replied, post #16 · Start Here › How to Ask · 12 Jul 2026 · 1 like A photograph of a vial is rarely useful and a photograph of a document usually is. Redact the identifiers before you post either.
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I joined for one answer and stayed for a year — what changed my mind Replied, post #77 · Start Here › Welcome · 12 Jul 2026 · 4 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
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Seven-day rolling means and why weekly readings mislead Replied, post #15 · Outcomes › Progress reports · 12 Jul 2026 · 20 likes Post #14 is right about the mechanism and I think understates the practical bit. If a pattern survives a rolling-mean treatment it is worth explaining. Most do not, and…
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Second pass at: Sleep apnoea improving and the equipment implications Replied, post #73 · Wellbeing › Sleep · 1 Jul 2026 · 13 likes On post #69 — agreed on the reasoning, with one qualification. Obstructive sleep apnoea: pre-existing OSA can worsen with weight before it improves (apnoea-hypopnoea…
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Journal club: semaglutide in MASH, and surrogate endpoints Replied, post #25 · Evidence › Journal club · 30 Jun 2026 · 21 likes Picking up post #22: that is the part I would want checked first. For anyone finding this later: the short answer on semaglutide in MASH is that it depends on one…
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Aggregate verification data across the directory, with caveats Replied, post #10 · Sourcing › Independent verification · 23 Jun 2026 · 1 like Same experience here, different supplier, so it is at least not unique to one of them.