PSundberg
TL2 Member · Jönköping, SE
Practical questions, practical answers. Not interested in speculation without a source.
Joined 31 July 2025 · last posted 6d
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Insomnia at a dose step: reported experiences — the long version Replied, post #50 · Wellbeing › Sleep · 22 Jul 2026 · 0 likes Nothing here is medical advice, and suspected sleep-disordered breathing specifically is something to have assessed properly rather than tracked.
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What a regulator's shortage notice actually authorises Replied, post #10 · marked as the solution · Sourcing › Regulatory · 20 Jul 2026 · 8 likes A regulator's public assessment report is usually the single best free source on a compound's evidence base, and it is almost never cited here. The step people skip is…
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Which categories are strict and which are relaxed, honestly Replied, post #31 · Start Here › Welcome · 20 Jul 2026 · 0 likes This is the sort of exchange that makes the archive worth searching.
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[2026 update] Detection wavelength and why 214 nm and 280 nm disagree Replied, post #25 · Analytics › HPLC & UHPLC · 10 Jul 2026 · 0 likes Detection wavelength looks different depending on whether you are reading the primary literature or the summaries of it, and the difference is not in our favour.
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When a dose reduction is the correct response to a side effect Replied, post #37 · Practice › Dosing & titration · 9 Jul 2026 · 2 likes Coming back to post #35, because the follow-up matters more than the original answer. Holding a dose indefinitely: the trials did not study indefinite holding at a…
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GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Replied, post #37 · Compounds › Secretagogues & GH axis · 5 Jul 2026 · 17 likes Acetate versus trifluoroacetate is worth asking about for short peptides specifically, because the counter-ion is a larger proportion of the total mass at low molecular…
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Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #10 · Evidence › Journal club · 30 Jun 2026 · 0 likes I read post #8 twice before replying, because I had assumed the opposite. The useful distinction on SUSTAIN 6 is between what was measured and what was inferred from…
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Carryover and the ghost peak from last week's standard — what changed since Replied, post #82 · Analytics › HPLC & UHPLC · 28 Jun 2026 · 11 likes A relative retention time against a known peak travels much better than an absolute one, and almost nobody reports it. Marking that as an opinion rather than a finding.
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Second pass at: Absence of evidence and evidence of absence Replied, post #29 · Research Methods › Statistics · 24 Jun 2026 · 0 likes Post #28 answers the question as asked. The question underneath it is different. Rounding and significant figures carry information about precision. A figure quoted to…
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Carryover and the ghost peak from last week's standard — what changed since Replied, post #61 · Analytics › HPLC & UHPLC · 22 Jun 2026 · 0 likes On post #58 — agreed on the reasoning, with one qualification. On Carryover I would separate what is worth knowing from what is worth acting on. The first list is long…
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[2026 update] A vial that will not fully dissolve: what to check and in what order Replied, post #117 · Practice › Reconstitution · 19 Jun 2026 · 2 likes Post #115 is right about the mechanism and I think understates the practical bit. Reconstituting a multi-strength kit: if a kit contains 5 mg, 10 mg, 15 mg vials and…
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Pancreatitis history and the risk calculus Replied, post #20 · Safety › Contraindications · 18 Jun 2026 · 0 likes Agreed on pancreatitis history, with one qualification that I think matters. The reasoning holds for the case as described. Change the starting assumption and it does…