VPoulsen
TL3 Regular · Coimbra, PT
Long-standing member. Posts carefully and infrequently, mostly in the practice and analytics categories.
Joined 11 October 2024 · last posted 2d
141Posts here
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Why catalogue breadth is not evidence of anything Replied, post #3 · Compounds › Other compounds · 26 Jul 2026 · 28 likes This subcategory exists because some people will research compounds outside the main groups discussed here. The standard of evidence and honesty about its limits…
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Pinch or no pinch, and how needle length changes the answer — what changed since Replied, post #59 · Practice › Administration · 19 Jul 2026 · 30 likes What I can speak to on Pinch is narrow, so I will keep it narrow rather than generalising from it. Beyond that boundary I do not know.
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Reading order for a first week here, and what to skip until later — what changed since Replied, post #39 · Start Here › Welcome · 13 Jul 2026 · 11 likes Useful. I have added it to my own notes with the date on it.
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Revisiting: What pooling buys you and what it destroys Replied, post #86 · Evidence › Meta-analyses · 10 Jul 2026 · 8 likes Appreciated. The plain phrasing does more work here than a longer post would.
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Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #91 · Evidence › Journal club · 8 Jul 2026 · 16 likes The most common failure mode is spending fifty minutes on the effect size and ten on the population. Reversing that ratio would improve most sessions.
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[2026 update] Journal club: what we got wrong in an earlier session Replied, post #5 · Evidence › Journal club · 6 Jul 2026 · 25 likes Bringing the previous paper on the same question makes the session much better and doubles the preparation. Worth doing every third session rather than every one.…
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[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #50 · Sourcing › Independent verification · 29 Jun 2026 · 18 likes I read post #48 twice before replying, because I had assumed the opposite. Interpreting a result looks different depending on whether you are reading the primary…
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Immortal time bias in a claims-database study — one year on Started this topic · Evidence › Study critique · 28 Jun 2026 · 26 likes Posting this under the heading it deserves: Immortal time bias in a claims-database study — one year on Everything below is what sits behind that. I would like to…
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Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #30 · Analytics › Impurities & related substances · 28 Jun 2026 · 23 likes Truncation products are substantially lower in mass and usually well separated chromatographically, which makes them the easiest class to see and the least likely to be…
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Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #20 · Practice › Dosing & titration · 27 Jun 2026 · 0 likes This follows post #17 rather than contradicting it. Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the…
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Why fasting instructions for oral semaglutide are not optional advice Replied, post #59 · Compounds › Oral incretins · 25 Jun 2026 · 3 likes The thirty-minute wait before eating is not conservatism. Food in the stomach materially reduces absorption of the oral product, and the instruction exists because the…
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Why side effects reset at each escalation and that is not a failure Replied, post #2 · Practice › Side effects · 24 Jun 2026 · 3 likes Discontinuation for adverse effects in the published trials was not rare at the higher doses. That number belongs in any discussion of tolerability and is usually left…