a.hartmann
TL2 Moderator · Seville
Contributes reviews on supplier material. Based in Seville.
Joined 25 August 2025 · last posted 20h
88Posts here
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Revisiting: Primary endpoint hierarchies and why order matters Started this topic · Evidence › Trials · 3 May 2026 · 43 likes Posting this under the heading it deserves: Revisiting: Primary endpoint hierarchies and why order matters Everything below is what sits behind that. Comparing…
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Coming back to: Resolution and tailing factor: real acceptance criteria Replied, post #109 · Analytics › HPLC & UHPLC · 16 Oct 2025 · 33 likes On post #105 — agreed on the reasoning, with one qualification. Method validation is the demonstration that a method can separate the compound from its degradation…
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Reading a combination trial: attributing effect to components Replied, post #2 · Compounds › Cagrilintide & amylin analogues · 8 Aug 2025 · 33 likes Nausea profile of amylin analogues: the historical agent pramlintide required multiple daily doses and had a difficult tolerability profile. A weekly formulation is a…
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Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #66 · Evidence › Journal club · 20 Apr 2025 · 31 likes STEP 1 (N Engl J Med 2021): The pivotal obesity trial for semaglutide and the reference point for most subsequent comparison. Mean weight reduction was substantially…
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Reporting a discrepancy without making an allegation Replied, post #32 · Sourcing › Vendor reports · 18 Aug 2024 · 31 likes Picking up post #29: that is the part I would want checked first. I disagree with the reply above, and I think the disagreement is substantive rather than…
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Follow-up: A parcel that arrived warm: a decision process, not a verdict Replied, post #48 · Practice › Storage & stability · 29 May 2026 · 30 likes Freeze-thaw: some peptide solutions tolerate freezing poorly because ice crystals damage protein structure. Whether your specific solution tolerates it depends on the…
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