bias_variance
TL4 Biostatistician · Aarhus, DK
Biostatistician. I am the person who asks what the estimand was. Sorry in advance.
Joined 12 May 2024 · last posted 2h · groups: journal-club, trust-level-4
224Posts here
4Topics
3Solutions
7.1kLikes received
4.3kLikes given
35Badges
692Days visited
23kPosts read
Stated areas
Recent activity
Full stream-
GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Replied, post #54 · Compounds › Secretagogues & GH axis · 28 Jul 2026 · 4 likes Reconstitution volumes in this family are often small enough that dead volume in the syringe is a meaningful fraction of the dose. A fixed-needle insulin syringe is…
-
What to bring: records that a clinician can actually use — a second dataset Replied, post #83 · Clinical › Prescriber conversations · 27 Jul 2026 · 30 likes A second opinion is a normal part of medicine rather than an accusation, and asking how to obtain one is a legitimate question. I have no interest in any supplier named…
-
[2026 update] Detection wavelength and why 214 nm and 280 nm disagree Replied, post #73 · Analytics › HPLC & UHPLC · 26 Jul 2026 · 0 likes Detection wavelength is a good example of a question where the honest answer is boring and the interesting answers are unsupported. I would go with boring.
-
Common supplements people ask about, assessed one at a time Replied, post #87 · Practice › Interactions · 23 Jul 2026 · 2 likes Useful. I have added it to my own notes with the date on it.
-
PIONEER 6 cardiovascular safety, read as a safety trial rather than an efficacy one Replied, post #18 · Compounds › Oral incretins · 23 Jul 2026 · 4 likes Worth separating two things that post #14 runs together. Orforglipron is a small molecule rather than a peptide, which changes almost everything about how it is made,…
-
Seven-day rolling means and why weekly readings mislead Replied, post #65 · Outcomes › Progress reports · 20 Jul 2026 · 28 likes Worth separating two things that post #61 runs together. Small correction to my own earlier position on seven-day rolling. I had the units the wrong way round, which…
-
Why retatrutide discussion here is more cautious than elsewhere — one year on Replied, post #65 · Compounds › Retatrutide · 15 Jul 2026 · 4 likes Noted, and thank you for writing it out rather than summarising it.
-
Second pass at: When your prescriber and the evidence disagree Replied, post #50 · Clinical › Prescriber conversations · 14 Jul 2026 · 0 likes My position on prescriber is current rather than settled. I have revised it once already and I expect to again, so treat it accordingly.
-
Immortal time bias in a claims-database study — one year on Replied, post #23 · Evidence › Study critique · 14 Jul 2026 · 3 likes Adding a small correction to the Immortal time bias summary above rather than a disagreement with it. The substance holds; one of the figures is out by a factor that…
-
Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #77 · Analytics › Impurities & related substances · 14 Jul 2026 · 25 likes Appreciated. The plain phrasing does more work here than a longer post would.
-
Reading order for a first week here, and what to skip until later — what changed since Replied, post #42 · Start Here › Welcome · 14 Jul 2026 · 8 likes The moderation log is public. Every staff action is logged with the rule cited and the reasoning stated. If you get moderated, the explanation is there and it is worth…
-
Submitting a sample: the process end to end Replied, post #77 · Sourcing › Independent verification · 12 Jul 2026 · 0 likes No disagreement from me. Posting only so the question does not look ignored.
Maintains 2 documents
- STEP 1 — trial digestReview due 29 Sep 2026
- FLOW — trial digestReview due 25 Sep 2026