c.niemel
TL3 Regular · Pau, FR
Long-standing member. Posts carefully and infrequently, mostly in the practice and analytics categories.
Joined 13 January 2025 · last posted 15h
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Fixed versus detachable needles: the trade-offs — does this still hold? Replied, post #13 · Devices › Syringes & needles · 27 Jul 2026 · 4 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
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Tracking semaglutide's approved indications across jurisdictions, dated Replied, post #20 · Compounds › Semaglutide · 27 Jul 2026 · 20 likes The 165 to 184 hour range: that is roughly 7 to 7.6 days, which is why the weekly schedule works. Below 4 half-lives you are not approaching steady state yet, which is…
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Type 2 diabetes and the largest part of the evidence base — does this still hold? Replied, post #23 · Clinical › Comorbidities · 27 Jul 2026 · 0 likes I read post #21 twice before replying, because I had assumed the opposite. Chronic kidney disease: compounds in this class have renal benefit in people with kidney…
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Private prescribing in the UK: what is actually involved Replied, post #75 · Regional › UK & Ireland · 25 Jul 2026 · 0 likes I read post #73 twice before replying, because I had assumed the opposite. Supply and shortage resilience: both UK and Ireland sourced primarily from European suppliers…
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Tracking a shortage from primary sources rather than rumour Replied, post #108 · Access › Shortages · 17 Jul 2026 · 25 likes Dose hold versus tapering: if a temporary shortage forces a gap, holding your dose and resuming when supply returns is different from gradually tapering. The two are…
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Micro-titration: a disputed topic, argued properly Replied, post #105 · Practice › Dosing & titration · 15 Jul 2026 · 7 likes How the published trials escalated: they used specific step sizes and intervals. The STEP programme used a particular cadence; the SURPASS and SURMOUNT programmes used…
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Journal club: LEADER as the historical anchor Replied, post #103 · Evidence › Journal club · 12 Jul 2026 · 6 likes Picking up post #100: that is the part I would want checked first. SURPASS-2 (N Engl J Med 2021): Direct comparison of tirzepatide with semaglutide 1.0 mg. The 1.0 mg…
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Osteoarthritis and mechanical versus metabolic improvement — one year on Replied, post #28 · Clinical › Comorbidities · 11 Jul 2026 · 0 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
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Revisiting: The best-written scientific paper you have read Replied, post #81 · Lounge › Off topic · 10 Jul 2026 · 30 likes Industry and supply chain: post about manufacturing, pharmaceutical economics, or market dynamics if you have something substantive to contribute.
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Revisiting: Liver enzymes drifting down and what that usually means Replied, post #54 · Clinical › Bloodwork · 9 Jul 2026 · 0 likes Picking up post #51: that is the part I would want checked first. Biological variation: the person-to-person variation in a biomarker for a healthy person is larger…
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How shortages have affected compounding permissions Replied, post #23 · Access › Shortages · 8 Jul 2026 · 0 likes Resuming after a gap: after a gap of days or a few weeks, most people resume at the dose they were on when they stopped. Gaps of months might require retitration…
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Comparing documentation quality across the directory, tabulated Replied, post #9 · Sourcing › Vendor reports · 8 Jul 2026 · 0 likes What "verified" means on our pages: specific lots were independently measured on stated dates by named services and results were consistent with the supplier's…