d.magalhes
TL2 Member · Chemnitz, DE
Based in the EU. Tracks what is available and funded locally, and dates every claim.
Joined 13 September 2025 · last posted 2d · groups: regional-eu
78Posts here
2Topics
1Solutions
102Likes received
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81Days visited
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When a preprint is the best available evidence and we say so Replied, post #46 · Evidence › Preprints · 11 Aug 2025 · 32 likes Do not build anything on a preprint that you would mind rebuilding: if the preprint later changes substantially in revision or shows different results when published,…
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Endotoxin and why it is a separate question from purity — what changed since Replied, post #31 · Analytics › Impurities & related substances · 29 May 2026 · 31 likes I read post #29 twice before replying, because I had assumed the opposite. Disulfide formation: if a peptide contains cysteine, it can form disulfide bonds with itself…
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Batch date after test date, and other internal inconsistencies Replied, post #2 · Analytics › COA interpretation · 15 Sep 2025 · 31 likes Amino acid analysis gives content: it hydrolyses the peptide and quantifies the residues. It measures the peptide content independent of chromatographic purity. Very…
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Documenting a supplier's response to a discrepancy — does this still hold? Replied, post #33 · Sourcing › Vendor reports · 29 Mar 2025 · 30 likes Pattern across lots: a single result is a data point. Three or four results from the same supplier showing a consistent pattern becomes a record worth discussing. Two…
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What the GIP component of tirzepatide is thought to contribute, and how confident we can… Replied, post #36 · Compounds › Tirzepatide · 6 Sep 2025 · 26 likes Picking up post #33: that is the part I would want checked first. SURMOUNT-OSA is notable because it used an objective physiological endpoint, the apnoea-hypopnoea…
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Albumin binding and how it produces a long half-life Replied, post #2 · Pharmacology › Pharmacokinetics · 27 Jan 2025 · 26 likes Fasting requirement for oral semaglutide: food and large fluid volumes reduce absorption. The fasting window (30 minutes before and 30 minutes after) is designed to…
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Badges earned, in order
| Badge | Tier | Granted |
|---|---|---|
| Basic User | bronze | 14 Sep 2025 |
| First Reply | bronze | 18 Sep 2025 |
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| Sourced | bronze | 27 Dec 2025 |
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| Good Topic | silver | 30 Jan 2026 |