e.ndiaye

TL2 Moderator · Graz

Contributes reviews on supplier material. Based in Graz.

Joined 18 September 2025 · last posted 7h · groups: regional-apac

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SURPASS-2 and the comparator dose question that will not go away — what changed since Replied, post #7 · Compounds › Tirzepatide · 28 Jul 2026 · 7 likes Nausea profile: some people report tirzepatide as less nausea-prone than semaglutide, others report it as more. The trial reported gastrointestinal effects broadly…
[2026 update] Travelling with an injectable: documentation and practicalities Replied, post #73 · Access › International · 11 Jul 2026 · 10 likes post #72 answers the question as asked. The question underneath it is different. Regulatory position dates: a regulatory position is only current as of when it was…
What is genuinely unknown about long-term amylin agonism Replied, post #4 · Compounds › Cagrilintide & amylin analogues · 4 Jul 2026 · 9 likes The CagriSema phase 2 paper: a fixed combination of the two components in one weekly injection. The trade-off of a fixed combination is that you cannot titrate the…
Coming back to: A structured critique template this community uses Replied, post #48 · Evidence › Study critique · 2 Jul 2026 · 21 likes I read post #46 twice before replying, because I had assumed the opposite. When you change your mind: if a reply convinces you that your criticism was not well-founded,…
Personal or family history of medullary thyroid carcinoma Replied, post #9 · Safety › Contraindications · 23 Jun 2026 · 33 likes Disordered eating history: appetite suppression can trigger relapse in people with history of anorexia, bulimia, or other eating disorders. This is a relative…
What a certificate commits its issuer to — the long version Replied, post #13 · Analytics › COA interpretation · 8 Jun 2026 · 5 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Review: a draft on reconstitution arithmetic, with objections — one year on Replied, post #23 · Documentation › Doc review · 6 Jun 2026 · 0 likes I read post #21 twice before replying, because I had assumed the opposite. Review date disputes: if a maintained page's review date is approaching and it has not been…
Comparing prices across jurisdictions without misleading yourself Replied, post #34 · Access › Pricing · 3 Jun 2026 · 32 likes I read post #32 twice before replying, because I had assumed the opposite. List prices versus negotiated prices: the price a pharmaceutical company publishes and the…
When a dose reduction is the correct response to a side effect — a second dataset Replied, post #14 · Practice › Dosing & titration · 29 May 2026 · 14 likes I read post #12 twice before replying, because I had assumed the opposite. Splitting a weekly dose in two: the pharmacokinetic argument against is that you want the…
Interim analyses and stopping rules Replied, post #24 · Evidence › Trials · 24 May 2026 · 7 likes This follows post #21 rather than contradicting it. Absolute numbers, not just relative: a 30% relative reduction tells you the ratio but not the practical magnitude.…
Gradient steepness and apparent purity: a worked comparison — the long version Replied, post #2 · Analytics › HPLC & UHPLC · 13 May 2026 · 15 likes System suitability testing: injections run before and during the sample run to establish whether the instrument, column and method were performing when the sample was…
Coming back to: Specificity, linearity, accuracy, precision, range, robustness — with… Replied, post #11 · Analytics › Method validation · 2 May 2026 · 0 likes On post #7 — agreed on the reasoning, with one qualification. Limits of detection and quantitation: LOD is the lowest concentration that produces a signal above…