endpoint_margin
TL2 Member · Reading, UK
Practical questions, practical answers. Not interested in speculation without a source.
Joined 6 September 2025 · last posted 2d · groups: regional-na
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UK access routes, dated and sourced — a second dataset Started this topic · Regional › UK & Ireland · 17 Oct 2024 · 49 likes Posting this under the heading it deserves: UK access routes, dated and sourced — a second dataset Everything below is what sits behind that. Documenting an access…
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Time to steady state after a dose increase Replied, post #91 · Pharmacology › Pharmacokinetics · 5 Nov 2024 · 31 likes Half-life: semaglutide ≈ 165–184 hours (about a week). Tirzepatide ≈ 5 days. Liraglutide ≈ 13 hours. The half-life determines how much accumulation happens at steady…
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Follow-up: Requesting a page: what makes a good request Replied, post #15 · Documentation › Wiki requests · 28 Mar 2025 · 30 likes Accessibility feedback: if you have trouble accessing or reading a maintained page (screen reader issues, contrast problems, small text) report it. Accessibility matters.
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[2026 update] Confounding by indication, explained with a concrete example Replied, post #67 · Evidence › Study critique · 19 Feb 2026 · 27 likes Coming back to post #65, because the follow-up matters more than the original answer. When you change your mind: if a reply convinces you that your criticism was not…
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Second pass at: The mass-error checker and its intended scope Replied, post #33 · Data & Tools › Calculators · 7 Oct 2025 · 27 likes I read post #31 twice before replying, because I had assumed the opposite. The calculators maintained on this site are open-source and verifiable. They are intended to…
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Molecular mass of semaglutide and why the figure differs between sources Replied, post #49 · Compounds › Semaglutide · 4 May 2026 · 24 likes On alcohol: the labelling does not contraindicate it, but it raises gastric irritation risk and semaglutide already does that. There is no published interaction study…
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