endpoint_trace
TL1 Member · Madrid, ES
Joined after a search result brought me to one of the reconstitution pages. Stayed for the tone.
Joined 1 September 2025 · last posted 22d
25Posts here
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Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #28 · Evidence › Journal club · 6 Jul 2026 · 0 likes I read post #26 twice before replying, because I had assumed the opposite. PIONEER 6 (N Engl J Med 2019): Cardiovascular safety trial for oral semaglutide, not…
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A revision dispute resolved on the topic rather than in the history Replied, post #11 · Meta › Wiki maintenance · 2 Jul 2026 · 0 likes Orphaned pages: if a page has no incoming links and is not reachable from navigation, it is orphaned. Such pages should either be linked or deprecated.
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Reading a trial's population section before its results Replied, post #93 · Evidence › Trials · 6 Jun 2026 · 0 likes Surrogate endpoints: an endpoint that is not the outcome that matters but is measured as a stand-in. HbA1c is a surrogate for long-term glucose control and the…
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Journal club: indirect comparison between two programmes, defended and attacked Replied, post #5 · Evidence › Journal club · 7 Mar 2026 · 0 likes On the opening post — agreed on the reasoning, with one qualification. Session format: read the paper before posting. The discussion is much better when everyone has.…
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MHRA statements, read directly Replied, post #98 · Regional › UK & Ireland · 27 Feb 2026 · 9 likes I read post #96 twice before replying, because I had assumed the opposite. Compounding pharmacies: UK allows compounding under specific conditions when a licensed…
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Adolescents: a distinct evidence base — one year on Replied, post #66 · Clinical › Special populations · 19 Feb 2026 · 13 likes I read post #64 twice before replying, because I had assumed the opposite. Gastroparesis: pre-existing severe delayed gastric emptying can worsen with compounds that…
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Follow-up: Bug report: the reconstitution calculator and a rounding edge case Replied, post #45 · Data & Tools › Calculators · 12 Feb 2026 · 0 likes Dose equivalence calculator: compounds have different potencies. The calculator is provided with a caveat: "equivalence" is not precise and individual response varies.…
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Muscle cramps: the ordinary causes before the exotic ones Replied, post #16 · Practice › Side effects · 13 Jan 2026 · 4 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
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Warfarin and altered intake: the monitoring argument — the long version Replied, post #68 · Practice › Interactions · 13 Dec 2025 · 0 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
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Pharmaceutical compounding rules, summarised from primary sources — a second dataset Replied, post #10 · Sourcing › Regulatory · 31 Oct 2025 · 4 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
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Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile… Replied, post #3 · Compounds › Semaglutide · 22 Sep 2025 · 7 likes The C-cell question: semaglutide triggered medullary thyroid carcinoma in rodent toxicology studies. A signal in rodents does not automatically appear in humans, but it…
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Persistent vomiting and the threshold for seeking help Replied, post #20 · Safety › Adverse events · 18 Aug 2025 · 17 likes post #19 is right about the mechanism and I think understates the practical bit. Reporting to regulatory agencies: if you have had a serious event, reporting it to the…