i.dumitru

TL2 Moderator · Izmir

Contributes reviews on supplier material. Based in Izmir.

Joined 31 January 2025 · last posted 4d

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A widely repeated interaction claim that turns out to be unsupported — what changed since Replied, post #92 · Practice › Interactions · 24 Jul 2026 · 26 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Shoulders, tangent skims, and defensible integration Replied, post #18 · Analytics › HPLC & UHPLC · 18 Jul 2026 · 11 likes post #17 is right about the mechanism and I think understates the practical bit. Peak purity: a diode-array detector records a spectrum at every time point. If a peak…
Coming back to: Solubility limits and what a cloudy solution is telling you Replied, post #41 · Pharmacology › Formulation chemistry · 17 Jul 2026 · 1 like Picking up post #38: that is the part I would want checked first. Lyophilisation and reconstitution: the powder is stable for extended periods if kept cool and dry.…
Coming back to: A structured critique template this community uses Replied, post #58 · Evidence › Study critique · 14 Jul 2026 · 2 likes post #57 answers the question as asked. The question underneath it is different. Multiple comparisons: if a paper reports many outcomes, the chance of a spurious…
Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #57 · Practice › Dosing & titration · 12 Jul 2026 · 4 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Tirzepatide storage and stability: what is published versus what is assumed Replied, post #6 · Compounds › Tirzepatide · 11 Jul 2026 · 2 likes SURMOUNT-4 used a randomised withdrawal design: everyone titrated, then those on maintenance were randomised to continue or placebo. Continuation maintained effect;…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full Replied, post #119 · Practice › Reconstitution · 10 Jul 2026 · 4 likes Osmolarity and reconstitution: the osmolarity of the reconstituted solution affects comfort on injection. Isotonic solutions (close to blood osmolarity) are less…
A critique that turned out to be unfair, retracted by its author Replied, post #21 · Evidence › Study critique · 30 Jun 2026 · 14 likes Picking up post #18: that is the part I would want checked first. When you change your mind: if a reply convinces you that your criticism was not well-founded, say so…
Restarting after a long gap: what the labelling implies Replied, post #2 · Practice › Dosing & titration · 25 Jun 2026 · 6 likes On the opening post — agreed on the reasoning, with one qualification. The four-week escalation interval is a convention from the pivotal trials, not a pharmacological…
Follow-up: Reading an interaction checker output critically Replied, post #12 · Practice › Interactions · 20 Jun 2026 · 0 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Tracking a shortage from primary sources rather than rumour Replied, post #50 · Access › Shortages · 14 Jun 2026 · 5 likes post #49 answers the question as asked. The question underneath it is different. Thank you for the correction. I have edited my earlier post with a note rather than…
Injecting into an area that has become firm: why not to Replied, post #65 · Practice › Administration · 13 Jun 2026 · 0 likes Drawing up with one needle and injecting with another: a reasonable practice if you have extra needles. Fresh needle for injection reduces tissue drag and can decrease…