j.fonseca

TL2 Moderator · Malmö

Contributes reviews on supplier material. Based in Malmö.

Joined 25 April 2025 · last posted 3d

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Request: tag synonyms surfaced in search Replied, post #26 · Meta › Feature requests · 25 Jul 2026 · 7 likes Worth separating two things that post #22 runs together. Alternatives: if you have thought of a way the current site might already serve your need, mention it. It helps…
Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #115 · Evidence › Journal club · 25 Jul 2026 · 5 likes SOUL (N Engl J Med 2025): Oral semaglutide cardiovascular outcomes. Extends the cardiovascular evidence to the oral formulation. Note that oral bioavailability is lower…
Talking to a therapist about this specifically Replied, post #22 · Wellbeing › Mental health · 18 Jul 2026 · 5 likes I read post #20 twice before replying, because I had assumed the opposite. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write…
Molecular mass of semaglutide and why the figure differs between sources Replied, post #103 · Compounds › Semaglutide · 17 Jul 2026 · 13 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
What a reversed-phase purity number actually is Replied, post #60 · Analytics › HPLC & UHPLC · 16 Jul 2026 · 0 likes Reversed-phase separates on hydrophobicity. A peptide is retained on a non-polar stationary phase and eluted by increasing organic solvent. For peptides the mobile…
What to bring: records that a clinician can actually use — a second dataset Replied, post #21 · Clinical › Prescriber conversations · 10 Jul 2026 · 4 likes How to ask for what you need: rather than "should I take this", frame it as "I understand the evidence for this shows X benefit in people with my condition; would it be…
Ultrasound and skinfolds: operator dependence in practice Replied, post #44 · Outcomes › Body composition · 5 Jul 2026 · 9 likes This follows post #41 rather than contradicting it. Visceral fat: DXA does not distinguish visceral (organ-associated) fat from subcutaneous fat. That distinction might…
Completing a dose with a second syringe, and the dead-volume arithmetic Replied, post #61 · Practice › Administration · 26 Jun 2026 · 22 likes Air bubbles in a subcutaneous injection: the honest risk assessment is low. Tiny air bubbles in subcutaneous tissue do not behave like an air embolism in a blood…
Journal club: SELECT, absolute risk, and how it was reported Replied, post #3 · Evidence › Journal club · 23 Jun 2026 · 1 like I read the opening post twice before replying, because I had assumed the opposite. PIONEER 6 (N Engl J Med 2019): Cardiovascular safety trial for oral semaglutide, not…
A supplier who responds to a discrepancy with silence — what changed since Replied, post #66 · Sourcing › Red flags · 19 Jun 2026 · 0 likes This follows post #63 rather than contradicting it. Unresponsiveness: a supplier that does not reply to reasonable requests for documentation or clarification is…
Does dual agonism explain the effect size, or is it dose? Replied, post #43 · Compounds › Tirzepatide · 18 Jun 2026 · 8 likes Worth separating two things that post #39 runs together. Dual agonism versus dose: how much of tirzepatide's effect is the GIP component and how much is simply…
Why we ask for units every single time, with three examples of what goes wrong Replied, post #16 · Start Here › How to Ask · 3 Jun 2026 · 4 likes Disagreeing with an answer you got: cite what you disagree with, say what contradicts it, and ask which one holds. Do not open with "I think you are wrong". Lead with…