j.lokken

TL2 Moderator · Wrocław

Contributes reviews on supplier material. Based in Wrocław.

Joined 3 February 2025 · last posted 2d

80Posts here

0Topics

0Solutions

107Likes received

81Likes given

17Badges

74Days visited

1.2kPosts read

Recent activity

Full stream

[2026 update] Documenting an adverse event properly Replied, post #22 · Safety › Adverse events · 26 Jul 2026 · 13 likes Acute kidney injury: rare but reported. Symptoms (decreased urine output, creatinine elevation) warrant urgent evaluation. Severe dehydration during weight loss is a…
eGFR fluctuation and the creatinine denominator problem — the long version Replied, post #26 · Clinical › Bloodwork · 22 Jul 2026 · 0 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
A calculator that gives a right answer to the wrong question Replied, post #35 · Data & Tools › Calculators · 18 Jul 2026 · 0 likes Offline use: all calculators are written in JavaScript and can be downloaded and run offline if desired. They do not require internet connectivity to function.
Forced degradation studies: designing one that is informative Replied, post #97 · Analytics › Method validation · 13 Jul 2026 · 30 likes On post #93 — agreed on the reasoning, with one qualification. Precision and repeatability: within-run and between-run variability of the method. Acceptance criterion…
Coming back to: Where the four-week escalation interval comes from, and what it is not Replied, post #19 · Practice › Dosing & titration · 9 Jul 2026 · 0 likes Reaching a dose and staying there for a year: the question of whether a stable dose remains effective over years is mostly answered by the withdrawal trials and by…
Follow-up: Sleep quality changes during weight loss Replied, post #65 · Wellbeing › Sleep · 9 Jul 2026 · 19 likes Appetite suppression and nighttime eating: if nighttime eating was a pattern, appetite suppression changes that pattern. Sleep can worsen if nighttime waking is…
Electrolyte supplements: which ones do anything Replied, post #46 · Nutrition & Training › Hydration & electrolytes · 3 Jul 2026 · 0 likes I read post #44 twice before replying, because I had assumed the opposite. Fluid intake: baseline needs increase with gastrointestinal effects and exercise. Thirst is…
Revisiting: What pooling buys you and what it destroys Replied, post #76 · Evidence › Meta-analyses · 2 Jul 2026 · 11 likes This follows post #73 rather than contradicting it. Sensitivity analysis: the authors re-run the meta-analysis excluding studies one at a time, or by quality, to see…
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #85 · Compounds › Semaglutide · 30 Jun 2026 · 8 likes Approved indications differ by jurisdiction and change. As of mid-2026 the weight-management indication is approved in many European jurisdictions but not all, and…
Why this subcategory is stricter about sourcing than most Replied, post #41 · Compounds › Secretagogues & GH axis · 10 Jun 2026 · 0 likes Reading a rodent study on a secretagogue without over-extrapolating: rodent studies can show a mechanism is plausible. They cannot show magnitude of effect in humans or…
Revisiting: Mean kinetic temperature explained without the mathematics Replied, post #36 · Practice › Storage & stability · 31 May 2026 · 18 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
[2026 update] Waist circumference technique and its repeatability Replied, post #13 · Outcomes › Progress reports · 30 May 2026 · 0 likes Seasonal patterns: some people report weight loss is slower in winter than summer. Body composition and activity changes might contribute. Noting the season is useful…