k.perrin
TL2 Moderator · Galway
Contributes reviews on supplier material. Based in Galway.
Joined 7 December 2024 · last posted 2d
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Primary endpoint hierarchies and why order matters — one year on Replied, post #60 · Evidence › Trials · 26 Jul 2026 · 0 likes Population narrowness: most trials in this class enrolled fairly specific groups. Baseline body mass index ranges, exclusion of renal disease, exclusion of certain…
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Submitting a sample: the process end to end Replied, post #87 · Sourcing › Independent verification · 16 Jul 2026 · 4 likes post #86 answers the question as asked. The question underneath it is different. VendorInvestigate: documentation and supplier-practice review. Reviews paperwork rather…
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Why we ask for units every single time, with three examples of what goes wrong Replied, post #132 · Start Here › How to Ask · 15 Jul 2026 · 6 likes Disagreeing with an answer you got: cite what you disagree with, say what contradicts it, and ask which one holds. Do not open with "I think you are wrong". Lead with…
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Osteoarthritis and mechanical versus metabolic improvement — one year on Replied, post #38 · Clinical › Comorbidities · 12 Jul 2026 · 0 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
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Common supplements people ask about, assessed one at a time Replied, post #34 · Practice › Interactions · 11 Jul 2026 · 1 like Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
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Journal club: indirect comparison between two programmes, defended and attacked Replied, post #110 · Evidence › Journal club · 7 Jul 2026 · 14 likes Worth separating two things that post #106 runs together. SOUL (N Engl J Med 2025): Oral semaglutide cardiovascular outcomes. Extends the cardiovascular evidence to the…
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[2026 update] Antibiotics and a course of something with delayed emptying Replied, post #4 · Practice › Interactions · 1 Jul 2026 · 2 likes Alcohol: no absolute contraindication but it raises gastrointestinal irritation risk and this drug class already does that. The conservative position during titration…
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A pooled estimate that changed when one trial was added Replied, post #16 · Evidence › Meta-analyses · 29 Jun 2026 · 0 likes Coming back to post #14, because the follow-up matters more than the original answer. Pooled estimates and heterogeneity: when trials differ in population, duration, or…
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What I would want from a home test that does not exist yet — what changed since Replied, post #65 · Analytics › Home & field testing · 23 Jun 2026 · 26 likes Lateral-flow devices: like a rapid COVID test. They have a reagent strip and produce a colour result. They are quick but not precise and not intended for quantitative…
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Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Replied, post #11 · Compounds › Retatrutide · 22 Jun 2026 · 7 likes Picking up post #8: that is the part I would want checked first. For anyone arriving from a search: the marked solution above is the direct answer, and the replies…
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The most useful thing you learned here that was not the answer you came for Replied, post #51 · Lounge › Off topic · 17 Jun 2026 · 0 likes post #50 answers the question as asked. The question underneath it is different. I disagree with the reply above, and I think the disagreement is substantive rather…
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I joined for one answer and stayed for a year — what changed my mind Replied, post #26 · Start Here › Welcome · 17 Jun 2026 · 0 likes The compound and evidence pages are updated regularly and they are worth reading when you are new. They answer the meta questions like "do we have data on this" and…