l.aguirre

TL2 · Catania

Contributes reviews on supplier material. Based in Catania.

Joined 2 October 2024 · last posted 1d · groups: newcomer-guides

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What a certificate commits its issuer to Replied, post #114 · Analytics › COA interpretation · 27 Jul 2026 · 29 likes A chromatogram supplied as a small image is legible for peak shape and not for baseline detail. That is enough to sanity-check an integration and not enough to…
Here for the analytics and not much else Replied, post #84 · Lounge › Introductions · 24 Jul 2026 · 26 likes If you are arriving from somewhere louder, the pace here will feel slow. A topic can sit for two days and then get a reply that is worth the wait. That is the design…
[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #116 · Sourcing › Independent verification · 23 Jul 2026 · 12 likes A supplier's own certificate is not independent. It can be posted, it is useful, and it is labelled for what it is. One of those cases where knowing the mechanism does…
Follow-up: How compounding permissions changed when supply normalised Replied, post #45 · Sourcing › Regulatory · 20 Jul 2026 · 11 likes I read post #43 twice before replying, because I had assumed the opposite. An indication approved for one age range does not extend to another, and paediatric…
About the Mass spectrometry category Replied, post #8 · Analytics › Mass spectrometry · 16 Jul 2026 · 16 likes Post #7 is right about the mechanism and I think understates the practical bit. Sample preparation for mass spectrometry can itself introduce modifications,…
Comparing my trajectory with the trial curves, carefully — a second dataset Replied, post #75 · Outcomes › Progress reports · 14 Jul 2026 · 7 likes The best progress reports here read as records rather than as arguments, and that difference is visible within a sentence. Happy to expand any of that if it is the…
Coming back to: A community side-effect dataset, with its response rate and biases Replied, post #94 · Data & Tools › Datasets · 11 Jul 2026 · 0 likes On community side-effect dataset the community has more anecdote than the confidence in this thread implies, and I include my own contribution in that.
Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Replied, post #19 · Evidence › Journal club · 6 Jul 2026 · 0 likes Where I would push back on the STEP 8 consensus is the confidence, not the direction. The direction looks right. The confidence is borrowed.
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Replied, post #20 · Compounds › Retatrutide · 1 Jul 2026 · 7 likes Coming back to post #18, because the follow-up matters more than the original answer. Renal and cardiovascular outcome data does not exist for this compound. Absence of…
Journal club: indirect comparison between two programmes, defended and attacked Replied, post #103 · Evidence › Journal club · 1 Jul 2026 · 0 likes STEP 1 (N Engl J Med 2021): The pivotal obesity trial for semaglutide and the reference point for most subsequent comparison. Mean weight reduction was substantially…
Journal club: SUSTAIN 6 and its retinopathy signal Started this topic · Evidence › Journal club · 26 Jun 2026 · 0 likes On the subject in the title: Journal club: SUSTAIN 6 and its retinopathy signal Working notes rather than a conclusion. Reading SUSTAIN 6 ( N Engl J Med , 2016) for the…
Reconstituting a multi-strength kit without mixing yourself up — what changed since Replied, post #32 · Practice › Reconstitution · 25 Jun 2026 · 0 likes Agreed on all of that, and I have nothing to add to it.