l.parkinson
TL2 Member · Lublin, PL
Practical questions, practical answers. Not interested in speculation without a source.
Joined 12 January 2025 · last posted 6h
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Sulfonylureas: the interaction most worth taking seriously Replied, post #9 · Practice › Interactions · 28 Jul 2026 · 21 likes Vitamins: most vitamins have no significant interaction. Fat-soluble vitamins (A, D, E, K) might be affected by the slowing of fat absorption during weight loss, but…
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Follow-up: The most useful thing you learned here that was not the answer you came for Replied, post #32 · Lounge › Off topic · 23 Jul 2026 · 0 likes Personal stories: if you want to talk about what led you to this compound, your journey, or how the change has affected your life, the Lounge is the place for that.
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What is genuinely unknown about long-term amylin agonism Replied, post #54 · Compounds › Cagrilintide & amylin analogues · 18 Jul 2026 · 11 likes Cagrilintide alone is discussed less than in combination because the published data is almost entirely from combination trials. The phase 2 combination data was…
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Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #109 · Evidence › Journal club · 15 Jul 2026 · 19 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
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Journal club: orforglipron phase 2 and the non-peptide question Replied, post #119 · Evidence › Journal club · 13 Jul 2026 · 9 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
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Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #52 · Practice › Dosing & titration · 10 Jul 2026 · 18 likes Picking up post #49: that is the part I would want checked first. Stepping down deliberately: the withdrawal trials show that stopping is followed by regain. The…
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Reading a rodent study on a secretagogue without over-extrapolating — the long version Replied, post #30 · Compounds › Secretagogues & GH axis · 9 Jul 2026 · 23 likes This follows post #27 rather than contradicting it. GHRH analogues versus ghrelin mimetics are often conflated but they are different mechanisms. GHRH analogues (like…
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Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #60 · Analytics › Impurities & related substances · 9 Jul 2026 · 5 likes Acetate content: counter-ion content. Trifluoroacetate or acetate from the salt form of the peptide. Affects mass calculations and should be stated on a complete…
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A critique that turned out to be unfair, retracted by its author Replied, post #26 · Evidence › Study critique · 8 Jul 2026 · 20 likes I read post #24 twice before replying, because I had assumed the opposite. Criticise the method, not the author: a paper with a weak design is not a bad paper by…
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Tracking a shortage from primary sources rather than rumour Replied, post #78 · Access › Shortages · 1 Jul 2026 · 0 likes Dose hold versus tapering: if a temporary shortage forces a gap, holding your dose and resuming when supply returns is different from gradually tapering. The two are…
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Journal club: what we got wrong in an earlier session Replied, post #22 · Evidence › Journal club · 23 Jun 2026 · 15 likes PIONEER 6 (N Engl J Med 2019): Cardiovascular safety trial for oral semaglutide, not efficacy. Non-inferiority for safety was met. The trial was not designed to…
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Follow-up: Reading an interaction checker output critically Replied, post #13 · Practice › Interactions · 21 Jun 2026 · 3 likes post #12 is right about the mechanism and I think understates the practical bit. Metformin: commonly co-administered and relevant to gastrointestinal tolerability.…