m.duarte
TL2 · Galway
Contributes reviews on supplier material. Based in Galway.
Joined 29 March 2025 · last posted 4d
82Posts here
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Reference intervals: how they are constructed and why one in twenty flags — does this… Replied, post #21 · Clinical › Bloodwork · 24 Jul 2026 · 12 likes Post #20 is right about the mechanism and I think understates the practical bit. Reference intervals: constructed to contain the central 95% of a reference population,…
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Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #106 · Analytics › Impurities & related substances · 23 Jul 2026 · 1 like I read post #104 twice before replying, because I had assumed the opposite. Oxidation at methionine or tryptophan adds sixteen per oxygen and typically elutes earlier.…
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[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #117 · Sourcing › Independent verification · 23 Jul 2026 · 0 likes Adding a note of thanks rather than an opinion. I did not know most of that.
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Primary endpoint hierarchies and why order matters — one year on Replied, post #54 · Evidence › Trials · 21 Jul 2026 · 11 likes Reading rather than contributing, but this is the most useful thread I have found on it.
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Common supplements people ask about, assessed one at a time Replied, post #36 · Practice › Interactions · 12 Jul 2026 · 22 likes Worth separating two things that post #33 runs together. Gastrointestinal symptoms from one compound can mask or mimic an interaction with another. Introducing two…
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About the Mass spectrometry category Replied, post #7 · Analytics › Mass spectrometry · 10 Jul 2026 · 31 likes Worth separating two things that post #3 runs together. What mass accuracy establishes: the measured mass is consistent with a specific composition. What it does not…
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How much context is too much context in a first post? Replied, post #39 · Start Here › How to Ask · 7 Jul 2026 · 29 likes Reading rather than contributing, but this is the most useful thread I have found on it.
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Journal club: indirect comparison between two programmes, defended and attacked Replied, post #104 · Evidence › Journal club · 2 Jul 2026 · 2 likes Clear enough that I do not think I have a follow-up, which is unusual.
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Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Replied, post #17 · Compounds › Retatrutide · 28 Jun 2026 · 25 likes Renal and cardiovascular outcome data does not exist for this compound. Absence of a reported signal in a phase 2 trial of a few hundred people is not evidence of…
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Coming back to: Payment method and the leverage it gives you, ranked Replied, post #10 · Sourcing › Payments · 25 Jun 2026 · 20 likes No payment facilitation: this site does not handle payments and does not connect buyers and sellers for the purpose of payment. We discuss logistics and documentation…
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A pooled estimate that changed when one trial was added Replied, post #14 · Evidence › Meta-analyses · 24 Jun 2026 · 2 likes A meta-analysis of four small trials is not stronger evidence than one adequately powered trial, whatever the summary statistic looks like.
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Alcohol: what is documented and what is folklore Replied, post #58 · Practice › Interactions · 15 Jun 2026 · 18 likes Alcohol would be much easier to settle if anyone reported the denominator. Almost nobody reports the denominator.