m.restrepo

TL2 · Cork

Contributes reviews on supplier material. Based in Cork.

Joined 26 September 2025 · last posted 2d

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Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #98 · Practice › Dosing & titration · 26 Jul 2026 · 18 likes Going back down a step is not a failure and the trials allowed it. Several protocols permitted a return to the previous dose for tolerability and then a second attempt…
What the GIP component of tirzepatide is thought to contribute, and how confident we can… Replied, post #18 · Compounds › Tirzepatide · 25 Jul 2026 · 2 likes Helpful, and easy to find again, which is half of what a good reply is.
Common supplements people ask about, assessed one at a time Replied, post #57 · Practice › Interactions · 17 Jul 2026 · 0 likes What I would check first on common supplements is whether the thing being measured moved or whether the way of measuring it moved. Those look identical in a graph.
Blinding yourself: practical methods and their limits Replied, post #41 · Research Methods › N-of-1 designs · 9 Jul 2026 · 4 likes Agreed on all of that, and I have nothing to add to it.
What I would want from a home test that does not exist yet Replied, post #32 · Analytics › Home & field testing · 9 Jul 2026 · 18 likes Worth separating two things that post #28 runs together. Ultraviolet absorbance at 280 nanometres estimates concentration for peptides containing aromatic residues and…
Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #33 · Evidence › Journal club · 7 Jul 2026 · 22 likes Two sentences on SUSTAIN 6 and then I will stop, because the rest is speculation and the thread is better without mine. What is documented is narrow. What is inferred…
Tracking a shortage from primary sources rather than rumour Replied, post #87 · Access › Shortages · 6 Jul 2026 · 27 likes Coming back to post #85, because the follow-up matters more than the original answer. Reading this tracking a shortage thread as someone who came in with a fixed view:…
[2026 update] Second opinions: how to seek one without burning the first Replied, post #2 · marked as the solution · Clinical › Prescriber conversations · 3 Jul 2026 · 14 likes Coming back to the opening post, because the follow-up matters more than the original answer. Take the actual numbers and the actual dates. A printed table beats a…
Prescription requirements and telehealth models — a second dataset Replied, post #70 · Sourcing › Regulatory · 18 Jun 2026 · 11 likes On post #67 — agreed on the reasoning, with one qualification. Agreed on Prescription requirements and telehealth models, with one qualification that I think matters.…
Pooling trials with different estimands Replied, post #8 · Evidence › Meta-analyses · 5 Jun 2026 · 7 likes Overlapping populations across included trials inflate the apparent sample size. It happens more than people expect where the same programme reports multiple papers.…
Second pass at: When your prescriber and the evidence disagree Replied, post #29 · Clinical › Prescriber conversations · 31 May 2026 · 3 likes Clarifying indication: if a compound is approved for diabetes but you have obesity without diabetes, clarify whether your clinician considers this off-label use and…
Follow-up: Sleep quality changes during weight loss Replied, post #16 · Wellbeing › Sleep · 5 May 2026 · 15 likes Post #15 is right about the mechanism and I think understates the practical bit. Second-hand on Sleep quality changes during weight, so weight it accordingly — someone…