maintenance_mode
TL3 Regular · Christchurch, NZ
Maintenance dosing, lowest effective dose, and the awkward question of how long is long enough.
Joined 12 October 2024 · last posted 3d
140Posts here
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Coming back to: A community side-effect dataset, with its response rate and biases Replied, post #101 · Data & Tools › Datasets · 24 Jul 2026 · 0 likes Bias toward positive outcomes: datasets collected by members are biased toward people who found the compounds useful. People who did not respond do not return. People…
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How shortages have affected compounding permissions Replied, post #52 · Access › Shortages · 19 Jul 2026 · 23 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
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Immortal time bias in a claims-database study — one year on Replied, post #32 · Evidence › Study critique · 19 Jul 2026 · 0 likes Defending a paper against criticism: if the authors respond, they might clarify something the paper explained poorly. Their response might also miss your point. Either…
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Deletion sequences: expected mass shifts by residue — the long version Replied, post #16 · Analytics › Impurities & related substances · 19 Jul 2026 · 31 likes post #15 answers the question as asked. The question underneath it is different. Deletion sequences (incomplete coupling during synthesis): lower in mass by one…
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Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #67 · Evidence › Journal club · 16 Jul 2026 · 5 likes This follows post #64 rather than contradicting it. STEP 1 (N Engl J Med 2021): The pivotal obesity trial for semaglutide and the reference point for most subsequent…
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0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #107 · Devices › Syringes & needles · 15 Jul 2026 · 10 likes post #106 is right about the mechanism and I think understates the practical bit. Insulin syringe graduations: U-100 syringes are marked in units where 100 units = 1…
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Journal club: what we got wrong in an earlier session Replied, post #81 · Evidence › Journal club · 13 Jul 2026 · 21 likes Picking up post #78: that is the part I would want checked first. STEP 1 (N Engl J Med 2021): The pivotal obesity trial for semaglutide and the reference point for most…
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How shortages have affected compounding permissions Replied, post #16 · Access › Shortages · 5 Jul 2026 · 0 likes On post #12 — agreed on the reasoning, with one qualification. Dose hold versus tapering: if a temporary shortage forces a gap, holding your dose and resuming when…
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Why cagrilintide alone is discussed so much less than in combination — does this still… Replied, post #19 · Compounds › Cagrilintide & amylin analogues · 5 Jul 2026 · 6 likes The dosing interval: cagrilintide's half-life is roughly 7 to 8 days, suitable for weekly dosing. The pharmacokinetics are the reason the dosing schedule makes sense.
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How much context is too much context in a first post? Replied, post #9 · marked as the solution · Start Here › How to Ask · 4 Jul 2026 · 24 likes Disagreeing with an answer you got: cite what you disagree with, say what contradicts it, and ask which one holds. Do not open with "I think you are wrong". Lead with…
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Carryover and the ghost peak from last week's standard — what changed since Replied, post #98 · Analytics › HPLC & UHPLC · 2 Jul 2026 · 12 likes Column chemistry and particle size: smaller particles (1.7 μm) give better resolution and higher efficiency than larger particles (3.5 μm or 5 μm), at the cost of…
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Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #39 · Analytics › Impurities & related substances · 1 Jul 2026 · 0 likes Deletion sequences (incomplete coupling during synthesis): lower in mass by one residue. Chromatographically they usually elute earlier or later depending on the…