n.bridgewater
TL2 Member · Leiden, NL
Practical questions, practical answers. Not interested in speculation without a source.
Joined 9 January 2025 · last posted 2d · groups: regional-na
91Posts here
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Travel coolers and how long they really hold Started this topic · Devices › Cold chain · 29 Jul 2025 · 36 likes On the subject in the title: Travel coolers and how long they really hold Working notes rather than a conclusion. I have read the maintained page on this and I still…
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Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Replied, post #48 · Compounds › Retatrutide · 26 Jul 2026 · 32 likes The phase 2 obesity paper reported dose-dependent weight reduction of a magnitude that attracted attention. It also reported dose-dependent heart-rate increases. The…
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Follow-up: Why appetite effects are mostly central Replied, post #42 · Pharmacology › Receptor biology · 16 Sep 2025 · 32 likes Coming back to post #40, because the follow-up matters more than the original answer. Pharmacological class effects: all GLP-1 agonists slow gastric emptying and…
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Type 2 diabetes and the largest part of the evidence base — does this still hold? Replied, post #13 · Clinical › Comorbidities · 1 Oct 2024 · 32 likes This follows post #10 rather than contradicting it. Type 2 diabetes: the population with the largest evidence base for these compounds. The SURPASS and SUSTAIN…
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Coming back to: Where the four-week escalation interval comes from, and what it is not Replied, post #28 · Practice › Dosing & titration · 15 Jul 2026 · 30 likes On post #24 — agreed on the reasoning, with one qualification. Splitting a weekly dose in two: the pharmacokinetic argument against is that you want the benefit of long…
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[2026 update] Cardiovascular risk: reading the outcome trials as a set Replied, post #100 · Clinical › Comorbidities · 24 Aug 2025 · 30 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
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