n.szabo
TL2 Moderator · Gdańsk
Contributes reviews on supplier material. Based in Gdańsk.
Joined 24 March 2025 · last posted 5h
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Sleep quality changes during weight loss Replied, post #32 · Wellbeing › Sleep · 28 Jul 2026 · 2 likes Obstructive sleep apnoea: pre-existing OSA can worsen with weight before it improves (apnoea-hypopnoea index goes up as soft tissue inflames before weight is lost).…
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Journal club: indirect comparison between two programmes, defended and attacked Replied, post #129 · Evidence › Journal club · 25 Jul 2026 · 0 likes TRIUMPH (ongoing): Retatrutide phase 3. No results yet. Nothing should be attributed to it because it has not finished. When it does, this discussion will return to it.
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Receptor desensitisation as a tolerance hypothesis, and its weak evidence Replied, post #54 · Pharmacology › Receptor biology · 24 Jul 2026 · 23 likes Glucagon receptor agonism: glucagon receptor agonism increases energy expenditure and promotes hepatic fat oxidation. The mechanism is distinct from GLP-1 and GIP…
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Composite endpoints and the component doing the work Replied, post #7 · Evidence › Trials · 19 Jul 2026 · 0 likes I read post #5 twice before replying, because I had assumed the opposite. Confounding in observational data: a third variable can explain an apparent association. In a…
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What to bring: records that a clinician can actually use — a second dataset Replied, post #32 · Clinical › Prescriber conversations · 13 Jul 2026 · 20 likes Discussing off-label dosing: if you want to dose differently than the label specifies (slower titration, higher final dose), discussing that explicitly and…
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Stability of BPC-157 in solution: what has been measured — one year on Replied, post #88 · Compounds › Repair & healing peptides · 10 Jul 2026 · 9 likes Worth separating two things that post #84 runs together. TB-500 is usually the 7-residue actin-binding fragment of thymosin beta-4, not the full 43-residue protein. The…
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Common supplements people ask about, assessed one at a time Replied, post #17 · Practice › Interactions · 7 Jul 2026 · 32 likes Supplements and herbs: many have no established interaction. Some do. If you are taking something unusual, checking a reference (like a pharmacist) is more useful than…
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What to include when your question involves a chromatogram — one year on Replied, post #62 · Start Here › How to Ask · 4 Jul 2026 · 0 likes Disagreeing with an answer you got: cite what you disagree with, say what contradicts it, and ask which one holds. Do not open with "I think you are wrong". Lead with…
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[2026 update] Antibiotics and a course of something with delayed emptying Started this topic · Practice › Interactions · 29 Jun 2026 · 24 likes On the subject in the title: Antibiotics and a course of something with delayed emptying Working notes rather than a conclusion. Reporting something rather than asking…
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Alcohol: what is documented and what is folklore Replied, post #77 · Practice › Interactions · 26 Jun 2026 · 0 likes Separation timing versus clinically important interaction: a separation timing inconvenience (taking one medication 2 hours before or after another) is not the same as…
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Journal club: semaglutide in MASH, and surrogate endpoints Replied, post #24 · Evidence › Journal club · 23 Jun 2026 · 5 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
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Completing a dose with a second syringe, and the dead-volume arithmetic Replied, post #58 · Practice › Administration · 20 Jun 2026 · 22 likes Injection discomfort: comes from needle gauge (finer = less discomfort), volume (smaller = less discomfort), temperature (room temperature or warmed is less…