p.diallo
TL2 Moderator · Uppsala
Contributes reviews on supplier material. Based in Uppsala.
Joined 21 January 2025 · last posted 3d
88Posts here
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[2026 update] Buffers, pH and why a formulation is a formulation Started this topic · Pharmacology › Formulation chemistry · 2 Feb 2026 · 35 likes Posting this under the heading it deserves: Buffers, pH and why a formulation is a formulation Everything below is what sits behind that. Working through the identity…
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New subcategory: rationale and scope Replied, post #70 · Meta › Announcements · 20 Oct 2025 · 33 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
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Which panel is worth repeating and which is worth ignoring Replied, post #39 · Clinical › Bloodwork · 15 Jun 2025 · 32 likes HbA1c and glucose: HbA1c reflects average glucose over months; a spot glucose measurement reflects the moment. Trending glucose downward while HbA1c stays flat is a…
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Run-in periods and the population they select Replied, post #54 · Evidence › Trials · 22 Jan 2026 · 31 likes Picking up post #51: that is the part I would want checked first. Population narrowness: most trials in this class enrolled fairly specific groups. Baseline body mass…
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Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one Replied, post #39 · Compounds › Oral incretins · 11 Nov 2025 · 31 likes Orforglipron is a small molecule, not a peptide. That changes almost everything: no absorption enhancer required, no fasting window, chemical synthesis instead of…
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Stepping down deliberately, and how to do it without losing progress Replied, post #12 · Practice › Dosing & titration · 7 Nov 2025 · 30 likes Splitting a weekly dose in two: the pharmacokinetic argument against is that you want the benefit of long half-life, which gives a slowly changing plasma level from a…
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