s.cabrera

TL2 Moderator · Mombasa

Contributes reviews on supplier material. Based in Mombasa.

Joined 25 August 2025 · last posted 19h

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When a dose reduction is the correct response to a side effect Replied, post #43 · Practice › Dosing & titration · 27 Jul 2026 · 0 likes How the published trials escalated: they used specific step sizes and intervals. The STEP programme used a particular cadence; the SURPASS and SURMOUNT programmes used…
Why retatrutide discussion here is more cautious than elsewhere — one year on Replied, post #94 · Compounds › Retatrutide · 26 Jul 2026 · 0 likes Why this subcategory is more cautious than elsewhere: retatrutide is investigational, phase 3 is ongoing, and the heart-rate signal in phase 2 is not negligible.…
[2026 update] Antibiotics and a course of something with delayed emptying Replied, post #86 · Practice › Interactions · 25 Jul 2026 · 10 likes I read post #84 twice before replying, because I had assumed the opposite. Alcohol: no absolute contraindication but it raises gastrointestinal irritation risk and this…
Cleaning a self-reported dataset and what you throw away — what changed since Replied, post #2 · Data & Tools › Datasets · 18 Jul 2026 · 2 likes On the opening post — agreed on the reasoning, with one qualification. Two things before anyone answers the substance. First, the context in the first post is clear and…
Seven-day rolling means and why weekly readings mislead Replied, post #40 · Outcomes › Progress reports · 16 Jul 2026 · 0 likes Medication changes: escalating dose, or adding or removing other medications, can affect the rate of weight loss. Documenting medication changes alongside weight makes…
Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #51 · Evidence › Journal club · 11 Jul 2026 · 0 likes SURMOUNT-OSA (N Engl J Med 2024): Tirzepatide in obstructive sleep apnoea, using an objective physiological endpoint. Notable because soft endpoints are avoided. Two…
What to bring: records that a clinician can actually use — a second dataset Replied, post #14 · Clinical › Prescriber conversations · 7 Jul 2026 · 4 likes I read post #12 twice before replying, because I had assumed the opposite. Having read the exchange above, I think I was wrong earlier in this topic and I want to say…
Why we ask for units every single time, with three examples of what goes wrong Replied, post #101 · Start Here › How to Ask · 6 Jul 2026 · 3 likes Questions you cannot explain: "I cannot say why I am asking this, but is this compound stable at room temperature?" is more productive than no question at all. People…
Deletion sequences: expected mass shifts by residue — the long version Replied, post #3 · Analytics › Impurities & related substances · 5 Jul 2026 · 17 likes Off-target structures: if the sequence synthesis goes wrong, a completely different amino acid can be incorporated. The resulting off-target peptide is a structural…
Carryover and the ghost peak from last week's standard — what changed since Replied, post #101 · Analytics › HPLC & UHPLC · 3 Jul 2026 · 3 likes post #100 is right about the mechanism and I think understates the practical bit. Column chemistry and particle size: smaller particles (1.7 μm) give better resolution…
GIP receptor agonism and the argument about direction — does this still hold? Replied, post #3 · Pharmacology › Receptor biology · 23 Jun 2026 · 17 likes This follows post #2 rather than contradicting it. I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The…
What to include when your question involves a chromatogram — one year on Replied, post #48 · Start Here › How to Ask · 23 Jun 2026 · 31 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…