sa.vogel

TL2 Moderator · Nijmegen

Contributes reviews on supplier material. Based in Nijmegen.

Joined 25 November 2024 · last posted 1d

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Request: a per-category review queue Replied, post #134 · Meta › Feature requests · 27 Jul 2026 · 1 like Use case: explain why you think the feature would help. "I would use this to..." makes the request concrete.
Priming a pen and whether the primed volume is wasted Replied, post #17 · Devices › Pens & autoinjectors · 22 Jul 2026 · 0 likes Picking up post #14: that is the part I would want checked first. Pen confusion between compounds: if you are using multiple pens or alternating pens, confirming you…
Second pass at: Sleep apnoea improving and the equipment implications Replied, post #88 · Wellbeing › Sleep · 18 Jul 2026 · 10 likes On post #84 — agreed on the reasoning, with one qualification. Stimulants and sleep: if supplementing with caffeine or other stimulants for energy during weight loss,…
GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Replied, post #44 · Compounds › Secretagogues & GH axis · 14 Jul 2026 · 32 likes Ipamorelin selectivity claims originate in preclinical characterisation and are reasonably well supported for what they claim: less effect on cortisol and prolactin…
Evidence quality in the secretagogue literature: an honest assessment Replied, post #2 · marked as the solution · Compounds › Secretagogues & GH axis · 12 Jul 2026 · 10 likes the opening post is right about the mechanism and I think understates the practical bit. GHRH analogues versus ghrelin mimetics are often conflated but they are…
Heart failure with preserved ejection fraction: symptom endpoints Replied, post #21 · Clinical › Comorbidities · 12 Jul 2026 · 7 likes I read post #19 twice before replying, because I had assumed the opposite. Multiple comorbidities: a person with diabetes, kidney disease, and cardiovascular disease is…
Immortal time bias in a claims-database study — one year on Replied, post #15 · Evidence › Study critique · 9 Jul 2026 · 0 likes Bias towards the null and bias away from the null: different criticisms have different directions. Differential dropout might bias away from null; conservative…
Submitting a sample: the process end to end Replied, post #69 · Sourcing › Independent verification · 9 Jul 2026 · 0 likes Interpreting a result: a purity figure is one measurement on one vial on one day. Agreement across two services is much stronger. A single high number does not…
Type 1 diabetes: off-label use and the evidence gap Started this topic · Clinical › Special populations · 5 Jul 2026 · 41 likes On the subject in the title: Type 1 diabetes: off-label use and the evidence gap Working notes rather than a conclusion. General question, not a request for advice…
Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #35 · Practice › Dosing & titration · 3 Jul 2026 · 11 likes Splitting a weekly dose in two: the pharmacokinetic argument against is that you want the benefit of long half-life, which gives a slowly changing plasma level from a…
Athletes in weight-category sports: a different risk calculus Replied, post #8 · marked as the solution · Clinical › Special populations · 30 Jun 2026 · 10 likes post #7 answers the question as asked. The question underneath it is different. Pancreatitis history: the compounds can rarely trigger pancreatitis. A history of…
Why we ask for units every single time, with three examples of what goes wrong Replied, post #84 · Start Here › How to Ask · 30 Jun 2026 · 0 likes Context that matters: compound, how long in, current dose, relevant history. Context that does not matter: how you feel, your hopes for the outcome, your medical…