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titration_diary

TL3 Regular · Nottingham, UK

Two and a half years of weekly notes. I post the boring longitudinal data nobody else wants to keep.

Joined 12 February 2025 · last posted just now · groups: wiki-editors

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  • Reading a syringe in poor light, and how to avoid needing to Replied, post #3 · Devices › Syringes & needles · 28 Jul 2026 · 1 like I read the opening post twice before replying, because I had assumed the opposite. Practical note that does not fit anywhere else. Whatever you conclude from this…
  • Reading a home test result without over-claiming Replied, post #138 · Analytics › Home & field testing · 28 Jul 2026 · 4 likes Immunoassay limitations: tests that use antibodies have cross-reactivity limitations. An antibody raised to semaglutide will cross-react to some degree with tirzepatide…
  • What is genuinely unknown about long-term amylin agonism Replied, post #77 · Compounds › Cagrilintide & amylin analogues · 24 Jul 2026 · 27 likes Amylin signalling is distinct from GLP-1 signalling. Amylin slows gastric emptying and promotes satiety through a different receptor and different neural pathways. The…
  • Coming back to: Preparing for an appointment: one page, three questions Replied, post #39 · Clinical › Prescriber conversations · 23 Jul 2026 · 18 likes post #38 is right about the mechanism and I think understates the practical bit. Understanding stopping rules: what would prompt stopping the compound? Adverse effect,…
  • Endotoxin and why it is a separate question from purity — what changed since Replied, post #82 · Analytics › Impurities & related substances · 19 Jul 2026 · 33 likes Dimer and higher-order multimers: two or more peptide molecules bonded together. They appear at double the mass and higher. They may or may not separate from the…
  • Tirzepatide storage and stability: what is published versus what is assumed Replied, post #19 · Compounds › Tirzepatide · 15 Jul 2026 · 0 likes On post #15 — agreed on the reasoning, with one qualification. SURMOUNT-4 used a randomised withdrawal design: everyone titrated, then those on maintenance were…
  • Transit times by route, from a logged dataset Replied, post #8 · Sourcing › Logistics · 14 Jul 2026 · 15 likes This follows post #5 rather than contradicting it. Customs holds: if a parcel is held at customs and you can contact customs directly, declaring your personal use and…
  • eGFR fluctuation and the creatinine denominator problem — the long version Started this topic · Clinical › Bloodwork · 13 Jul 2026 · 8 likes eGFR fluctuation and the creatinine denominator problem — the long version — setting out what I have, and where I think it stops being reliable. Asking about a…
  • Asking a follow-up: new topic or new reply? Replied, post #51 · Start Here › How to Ask · 13 Jul 2026 · 16 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
  • A 5 mg vial and a 0.25 mg dose: the arithmetic in full Replied, post #110 · Practice › Reconstitution · 4 Jul 2026 · 5 likes Why "add 2 mL" is not an instruction: the powder in the vial takes up space. "Add 2 mL to a 10 mL vial" and "add 2 mL of diluent so the final volume is approximately 2…
  • Reading order for a first week here, and what to skip until later — what changed since Replied, post #6 · Start Here › Welcome · 2 Jul 2026 · 16 likes Off-topic posts that do not belong here belong in the Lounge instead. You are not in trouble if a moderator moves your post — they are just routing it to the right…
  • What a reversed-phase purity number actually is Replied, post #3 · Analytics › HPLC & UHPLC · 25 Jun 2026 · 0 likes Reversed-phase separates on hydrophobicity. A peptide is retained on a non-polar stationary phase and eluted by increasing organic solvent. For peptides the mobile…

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