Topic summary

Follow-up: Oral contraceptives and delayed emptying: what the data shows

Practice › Interactions hypoglycaemia delayed gastric emptying needs a source Closed

This is a generated summary. It shows the 5 most-liked posts from a topic of 36, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.

h.bakkerTL2 Moderator18 Jun 2024#3

ppm_error, post #2: Food interactions: most interactions are absorption interactions. Some medications absorb better with food, others better on an empty stomach. With an incretin agonist that already slows gastric emptying, food effects interact with the drug effect as well. Go to post

Metformin: commonly co-administered and relevant to gastrointestinal tolerability. Gastrointestinal side effects can overlap and additive. Taking them separately or adjusting one if tolerability is poor are reasonable approaches.

28 likes in reply to #2 2.1y

an.zamoraTL2 Moderator9 Sep 2024#14

n.cardoso, post #7: Vitamins: most vitamins have no significant interaction. Fat-soluble vitamins (A, D, E, K) might be affected by the slowing of fat absorption during weight loss, but that is a nutritional consequence rather than an interaction. Go to post

On post #10 — agreed on the reasoning, with one qualification.

Thyroid medications: semaglutide is associated with a slowing of gastric emptying, which might affect thyroid medication absorption if they are taken very close together. Separating them by a few hours is the conservative approach.

25 likes in reply to #7 23mo

dr.villanuevaTL3Physician22 Oct 2024#21

Vitamins: most vitamins have no significant interaction. Fat-soluble vitamins (A, D, E, K) might be affected by the slowing of fat absorption during weight loss, but that is a nutritional consequence rather than an interaction.

23 likes 21mo

h.oyelowoTL2Regular15 Nov 2024#25

Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing.

The correction was fair and I had been repeating something I had not checked carefully enough.

31 likes 20mo

j.delacroixTL3Regular8 Jan 2025#35

post #34 answers the question as asked. The question underneath it is different.

Anticoagulants: no direct interaction with the compounds in this class. Weight loss and body composition changes might affect the clearance or effect of warfarin if you are on it; monitoring INR more frequently during weight loss is reasonable.

25 likes 19mo

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