Practice · Administration

Injection discomfort: needle gauge, volume, temperature, technique — one year on

Practice › Administration missed dose aseptic technique injection site rotation needle gauge & length injection site reaction subcutaneous injection

a.thorneTL2Wiki editor19 Sep 2025#1

Posting this under the heading it deserves: Injection discomfort: needle gauge, volume, temperature, technique — one year on Everything below is what sits behind that.

Practical question with the units stated, because I have seen how quickly these go wrong without them.

I have a 5 mg vial of semaglutide and I am working to a 5.0 mg step. My syringes are U-100 insulin syringes, 0.3 mL barrel.

I can do the arithmetic and I have done it twice, getting the same answer both times, but I would like someone to check the reasoning rather than the number — specifically whether I have thought about the residual volume correctly, and whether the graduation I am landing on is one a person can actually read.

3 likes 10mo

p.mwangiTL2 Moderator7 Oct 2025#2

Worth separating two things that the opening post runs together.

Air bubbles in a subcutaneous injection: the honest risk assessment is low. Tiny air bubbles in subcutaneous tissue do not behave like an air embolism in a blood vessel. A few air bubbles are not a reason to restart the entire injection.

7 likes 10mo

dr_seongTL3Physician20 Oct 2025#3

a.thorne, post #1: Posting this under the heading it deserves: Injection discomfort: needle gauge, volume, temperature, technique — one year on Everything below is what sits behind that. Practical question with the units stated, because I have seen how quickly these go wrong without them. I have a 5 mg vial of semaglutide and I am working to a 5.0 mg… Go to post

Pinch or no pinch: the decision depends on needle length and on your own anatomy. A longer needle (8 mm and up) reaches subcutaneous tissue easily without a pinch. A shorter needle (4-6 mm) is safer with a gentle pinch. The pinch size matters less than people think; the injection angle matters more.

24 likes in reply to #1 9mo

This topic was referenced in

A site rotation scheme that is easy enough to actually follow — a second datasetPractice › Administration · 10 replies

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