Clinical · Special populations · continued

Pregnancy and pregnancy planning: contraindication and washout posts 121–123

Clinical › Special populations pregnancy & planning bariatric surgery history chronic kidney disease disordered eating Closed

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r.oyelaranTL2 Moderator23 Apr 2026#121

t.tulloch, post #70: Coming back to post #68, because the follow-up matters more than the original answer. Hepatic impairment: less is known about dosing in significant liver disease than in kidney disease. Extreme caution applies because the liver metabolises a large fraction of many medications. Go to post

I read post #119 twice before replying, because I had assumed the opposite.

Older adults: sarcopenia risk is higher, polypharmacy is common, and the clinical trials did not enroll many people over 75. Extrapolating to very old people is extrapolating beyond the data.

2 likes in reply to #70 3mo

k.farrugiaTL3Regular24 Apr 2026#122

Medullary thyroid carcinoma history: an absolute contraindication because of the preclinical findings in rodent toxicology. The history (personal or family, especially multiple endocrine neoplasia type 2) is an important screening question.

0 likes 3mo

m.yildizTL2 Moderator25 Apr 2026#123

Pregnancy and planning: these compounds are not approved for use in pregnancy. Planning windows (how long to wait before attempting pregnancy) are not formally established. Conservative approaches wait several months to allow clearance.

21 likes 3mo

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