Practice · Dosing & titration

Reaching a dose and staying there for a year: a longitudinal note

Practice › Dosing & titration worked example tirzepatide titration semaglutide missed dose dose reduction

resistance_firstTL2Regular6 Apr 2025#1

Reaching a dose and staying there for a year: a longitudinal note Writing it up because I had to work it out twice and would rather nobody else did.

I have read the maintained page on this and I still have a gap, so I am asking rather than guessing.

Context: retatrutide, 17 weeks in, currently at a dose I reached by the standard four-week steps. Everything below is my own record rather than anything a clinician told me.

The specific question is the one in the title. What I have already checked: the labelling summary on the relevant documentation page, the two most-linked topics in this subcategory, and my own notes from the last 13 weeks. What I could not find is whether the answer changes at higher doses or whether it is the same arithmetic throughout.

If the answer is "it depends", I would rather know what it depends on than be given a number.

0 likes 16mo

n.rowntreeTL3Regular18 Apr 2025#2

the opening post is right about the mechanism and I think understates the practical bit.

Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the kind that comes from remembering a figure instead of looking it up.

19 likes 15mo

h.castellanosTL2 Moderator27 Apr 2025#3

Reaching a dose and staying there for a year: the question of whether a stable dose remains effective over years is mostly answered by the withdrawal trials and by real-world reports. The dose does not seem to stop working, but the longest trials are not indefinitely long.

5 likes 15mo

This topic was referenced in

Holding a dose indefinitely: is there a documented downside?Practice › Dosing & titration · 32 replies

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