CSagredo
TL3 Regular · Oxford, UK
Reads the primary literature and posts summaries with page numbers. Prefers being corrected to being agreed with.
Joined 4 February 2025 · last posted 6d
125Posts here
2Topics
2Solutions
874Likes received
456Likes given
24Badges
223Days visited
2.9kPosts read
Stated areas
Recent activity
Full stream-
Designing a personal experiment that could change your mind — one year on Replied, post #79 · Research Methods › N-of-1 designs · 22 Jul 2026 · 6 likes Statistical analysis of n-of-1 data: comparing before versus after with a t-test or similar is one approach. Plotting the data visually is another. Both are valid.
-
Pancreatitis history and the risk calculus Replied, post #31 · Safety › Contraindications · 21 Jul 2026 · 1 like History of pancreatitis: these compounds can rarely trigger pancreatitis. History of pancreatitis increases relative risk. That is a relative contraindication, not…
-
Heart failure with preserved ejection fraction: symptom endpoints Replied, post #24 · Clinical › Comorbidities · 16 Jul 2026 · 17 likes Hepatic steatosis and MASH: a phase 2 trial in semaglutide for steatohepatitis showed resolution was more frequent on treatment. Histological resolution is a surrogate…
-
Revisiting: Why the absence of controlled human data on BPC-157 matters more than people… Replied, post #33 · Compounds › Repair & healing peptides · 15 Jul 2026 · 8 likes post #32 answers the question as asked. The question underneath it is different. The distinction between "no evidence it works" and "evidence it does not work": we have…
-
Pages past their review date, listed — does this still hold? Replied, post #52 · Meta › Wiki maintenance · 14 Jul 2026 · 1 like Orphaned pages: if a page has no incoming links and is not reachable from navigation, it is orphaned. Such pages should either be linked or deprecated.
-
What is genuinely unknown about long-term amylin agonism Replied, post #29 · Compounds › Cagrilintide & amylin analogues · 12 Jul 2026 · 9 likes Nausea profile of amylin analogues: the historical agent pramlintide required multiple daily doses and had a difficult tolerability profile. A weekly formulation is a…
-
Muscle cramps: the ordinary causes before the exotic ones — a second dataset Replied, post #43 · Practice › Side effects · 11 Jul 2026 · 15 likes Picking up post #40: that is the part I would want checked first. Recognition and grading: nausea ranges from "noticeable" to "limiting". Constipation ranges from mild…
-
What consumer-accessible tests can and cannot determine — a second dataset Replied, post #69 · Analytics › Home & field testing · 9 Jul 2026 · 3 likes On post #65 — agreed on the reasoning, with one qualification. Enzyme assays: if you have an enzyme that reacts specifically with your compound, an enzyme-based assay…
-
How much context is too much context in a first post? Replied, post #60 · Start Here › How to Ask · 9 Jul 2026 · 0 likes On post #56 — agreed on the reasoning, with one qualification. Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly…
-
Primary endpoint hierarchies and why order matters — one year on Replied, post #37 · Evidence › Trials · 6 Jul 2026 · 0 likes The estimand: what the trial set out to estimate. Two trials can be identical in structure but estimate different things by using different handling rules for people…
-
NHS criteria and how they are applied in practice Replied, post #19 · Regional › UK & Ireland · 4 Jul 2026 · 0 likes NHS access has been restricted by commissioning criteria, not by licensing. Specialist weight-management services in many areas require prior weight-loss attempts, BMI…
-
Lean mass preservation: what the evidence supports — does this still hold? Replied, post #106 · Outcomes › Body composition · 1 Jul 2026 · 2 likes Comparison to published data: the trials reported mean fat and lean mass changes. Individual results vary around that mean. Being above or below average is not a sign…