Knowlton
TL3 Regular · Szeged, HU
Clinician. Posts general information only, and says so every time.
Joined 27 October 2024 · last posted 2d · groups: clinicians
145Posts here
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Peak-to-trough ratio at steady state for a weekly agent — the long version Replied, post #61 · Pharmacology › Pharmacokinetics · 26 Jul 2026 · 11 likes Worth separating two things that post #57 runs together. Individual variation: people vary in how quickly they absorb, distribute, metabolise, and excrete these…
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Coming back to: Delayed gastric emptying and oral medication absorption: which drugs… Replied, post #69 · Practice › Interactions · 25 Jul 2026 · 2 likes Alcohol: no absolute contraindication but it raises gastrointestinal irritation risk and this drug class already does that. The conservative position during titration…
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Journal club: what we got wrong in an earlier session Replied, post #118 · Evidence › Journal club · 25 Jul 2026 · 31 likes SOUL (N Engl J Med 2025): Oral semaglutide cardiovascular outcomes. Extends the cardiovascular evidence to the oral formulation. Note that oral bioavailability is lower…
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Coming back to: Telehealth prescribing models in the US Replied, post #27 · Regional › North America · 24 Jul 2026 · 10 likes Regional variation in North America: access differs substantially by US state and Canadian province. Postcode is a major determinant of access.
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What a certificate commits its issuer to Replied, post #94 · Analytics › COA interpretation · 24 Jul 2026 · 5 likes Sterility testing is separate: chromatographic purity, mass spectrometry, and endotoxin testing all say nothing about whether a solution is sterile. If sterility…
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Coming back to: Where the four-week escalation interval comes from, and what it is not Replied, post #40 · Practice › Dosing & titration · 22 Jul 2026 · 29 likes How the published trials escalated: they used specific step sizes and intervals. The STEP programme used a particular cadence; the SURPASS and SURMOUNT programmes used…
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[2026 update] Regional warehouse stock versus direct despatch Replied, post #138 · Sourcing › Logistics · 18 Jul 2026 · 7 likes Documentation after arrival: photograph the parcel and its contents on arrival. If something later turns out wrong (damage, loss, wrong item) you have evidence of the…
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NHS criteria and how they are applied in practice Replied, post #33 · Regional › UK & Ireland · 17 Jul 2026 · 18 likes Compounding pharmacies: UK allows compounding under specific conditions when a licensed product is unavailable. That is not a front-line option but becomes relevant…
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Here for the analytics and not much else Replied, post #28 · Lounge › Introductions · 13 Jul 2026 · 6 likes Ongoing: you can post multiple introductions over time. If you return after a long break, reintroducing yourself is fine.
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Insurance and replacement policies, compared Replied, post #78 · Sourcing › Logistics · 10 Jul 2026 · 22 likes post #77 is right about the mechanism and I think understates the practical bit. For anyone arriving from a search: the marked solution above is the direct answer, and…
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Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #87 · Evidence › Journal club · 7 Jul 2026 · 0 likes I read post #85 twice before replying, because I had assumed the opposite. Session format: read the paper before posting. The discussion is much better when everyone…
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[2026 update] Area percent versus weight percent: the confusion that causes most arguments Replied, post #68 · Analytics › HPLC & UHPLC · 6 Jul 2026 · 15 likes Coming back to post #66, because the follow-up matters more than the original answer. Method validation is the demonstration that a method can separate the compound…