Nardone
TL2 Member · Dijon, FR
Practical questions, practical answers. Not interested in speculation without a source.
Joined 10 December 2024 · last posted 8d
85Posts here
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Second pass at: When your prescriber and the evidence disagree Replied, post #53 · Clinical › Prescriber conversations · 20 Jul 2026 · 30 likes Appreciated. The plain phrasing does more work here than a longer post would.
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An 18-month record including the parts that went badly Replied, post #74 · Outcomes › Progress reports · 19 Jul 2026 · 0 likes Nothing here is medical advice and a progress report is a description of what happened to one person under uncontrolled conditions. That is what the documentation says.…
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Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Replied, post #6 · Compounds › Retatrutide · 17 Jul 2026 · 21 likes Post #5 answers the question as asked. The question underneath it is different. Hepatic effects: glucagon receptor agonism promotes hepatic fat oxidation, which is…
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Washout with a one-week half-life: the arithmetic — does this still hold? Replied, post #41 · Research Methods › N-of-1 designs · 15 Jul 2026 · 0 likes Post #40 is right about the mechanism and I think understates the practical bit. Washout is well covered in the tag pages, and the older discussions are better than the…
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Specificity, linearity, accuracy, precision, range, robustness — with real criteria Replied, post #42 · Analytics › Method validation · 12 Jul 2026 · 10 likes Bookmarking this. I will come back when I have something worth adding.
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Private prescribing in the UK: what is actually involved Replied, post #61 · Regional › UK & Ireland · 10 Jul 2026 · 5 likes Post #59 is right about the mechanism and I think understates the practical bit. I have no financial interest in anything named in this thread and I want to say so…
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[2026 update] Detection wavelength and why 214 nm and 280 nm disagree Replied, post #17 · Analytics › HPLC & UHPLC · 7 Jul 2026 · 0 likes Worth stating the null on Detection wavelength before we explain it: the observation may be nothing. That possibility deserves a sentence and usually does not get one.
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Designing a personal experiment that could change your mind — one year on Replied, post #71 · Research Methods › N-of-1 designs · 6 Jul 2026 · 1 like Appreciated. The plain phrasing does more work here than a longer post would.
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What a simple presence test is genuinely useful for Replied, post #2 · Analytics › Home & field testing · 5 Jul 2026 · 3 likes False positives and false negatives: no test has 100% sensitivity and 100% specificity. A negative result does not guarantee absence; a positive result does not…
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How much context is too much context in a first post? Replied, post #16 · Start Here › How to Ask · 5 Jul 2026 · 8 likes Number your questions if there is more than one. It sounds fussy. It means the answer can be numbered back, and you find out which one nobody addressed.
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Follow-up: Reading an interaction checker output critically Replied, post #31 · Practice › Interactions · 4 Jul 2026 · 0 likes Anything that also slows gut motility compounds the same mechanism. That is a plausibility argument rather than a documented interaction, and it should be labelled as…
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Review: a draft on reconstitution arithmetic, with objections — one year on Replied, post #38 · Documentation › Doc review · 3 Jul 2026 · 0 likes A methods point on draft on reconstitution arithmetic rather than a substantive one: if the comparison is not like for like, the difference you are measuring is the…