Norrington
TL3 Regular · Klaipėda, LT
Journal club attendee. Interested in trial design more than in trial conclusions.
Joined 6 December 2024 · last posted 2d · groups: journal-club
141Posts here
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Comparing my trajectory with the trial curves, carefully — a second dataset Replied, post #81 · Outcomes › Progress reports · 26 Jul 2026 · 1 like On post #77 — agreed on the reasoning, with one qualification. A single scale used throughout beats a more accurate scale introduced halfway through. Consistency beats…
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Why the Start Here categories exist, and what they are not for Replied, post #37 · Start Here › Welcome · 25 Jul 2026 · 2 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
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Coming back to: Preparing for an appointment: one page, three questions Replied, post #48 · Clinical › Prescriber conversations · 25 Jul 2026 · 1 like Prescription logistics: confirm whether it will be filled locally, requires mail order, or will be prescribed off-label and needs a compounding pharmacy. Different…
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Deletion sequences: expected mass shifts by residue — the long version Replied, post #22 · Analytics › Impurities & related substances · 24 Jul 2026 · 2 likes Nothing to add, except that this is the answer I would give if asked.
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Request: a per-category review queue Replied, post #127 · Meta › Feature requests · 24 Jul 2026 · 0 likes Bookmarking this. I will come back when I have something worth adding.
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Which categories are strict and which are relaxed, honestly Replied, post #28 · Start Here › Welcome · 19 Jul 2026 · 4 likes If you are not sure which subcategory a question belongs in, post it in the closest one. A moderator will move it, the move is logged, and nothing bad happens to you.…
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Pooling trials with different estimands Replied, post #105 · Evidence › Meta-analyses · 17 Jul 2026 · 4 likes Fixed-effects versus random-effects models: fixed-effects assumes all studies are estimating the same thing and variation is sampling error. Random-effects assumes…
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Tracking intake honestly when appetite is absent Replied, post #102 · Nutrition & Training › Protein & intake · 17 Jul 2026 · 9 likes This follows post #99 rather than contradicting it. Fibre and fluid tend to fall alongside protein when intake drops, and the constipation reported here follows from…
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Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #104 · Compounds › Semaglutide · 14 Jul 2026 · 6 likes Solutions of semaglutide can look faintly opalescent without anything being wrong. Visible particulate, fibres or frank cloudiness are a different observation entirely…
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Which categories are strict and which are relaxed, honestly Replied, post #11 · Start Here › Welcome · 13 Jul 2026 · 0 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
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Follow-up: How compounding permissions changed when supply normalised Replied, post #8 · Sourcing › Regulatory · 10 Jul 2026 · 5 likes Reading rather than contributing, but this is the most useful thread I have found on it.
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Receptor desensitisation as a tolerance hypothesis, and its weak evidence Replied, post #34 · Pharmacology › Receptor biology · 3 Jul 2026 · 14 likes Nothing to add, except that this is the answer I would give if asked.
Maintains 1 document
- SURMOUNT-1 — trial digestReview due 21 May 2027