buffer_margin
TL3 Regular · Poznań, PL
Journal club attendee. Interested in trial design more than in trial conclusions.
Joined 14 October 2024 · last posted 5d · groups: journal-club
136Posts here
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Follow-up: Reading an interaction checker output critically Replied, post #61 · Practice › Interactions · 23 Jul 2026 · 0 likes Vitamins: most vitamins have no significant interaction. Fat-soluble vitamins (A, D, E, K) might be affected by the slowing of fat absorption during weight loss, but…
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Journal club: what we got wrong in an earlier session Replied, post #99 · Evidence › Journal club · 19 Jul 2026 · 5 likes On post #95 — agreed on the reasoning, with one qualification. STEP 1 (N Engl J Med 2021): The pivotal obesity trial for semaglutide and the reference point for most…
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Coming back to: Delayed gastric emptying and oral medication absorption: which drugs… Replied, post #23 · Practice › Interactions · 14 Jul 2026 · 1 like Coming back to post #21, because the follow-up matters more than the original answer. Vitamins: most vitamins have no significant interaction. Fat-soluble vitamins (A,…
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What a certificate commits its issuer to — one year on Replied, post #106 · Analytics › COA interpretation · 10 Jul 2026 · 9 likes post #105 is right about the mechanism and I think understates the practical bit. When a document puts the specification in the result column, it has told you the…
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Shakes versus food: a pragmatic assessment Replied, post #22 · Nutrition & Training › Protein & intake · 7 Jul 2026 · 0 likes post #21 answers the question as asked. The question underneath it is different. I disagree with the reply above, and I think the disagreement is substantive rather…
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Coming back to: Delayed gastric emptying and oral medication absorption: which drugs… Replied, post #3 · marked as the solution · Practice › Interactions · 6 Jul 2026 · 16 likes Alcohol: no absolute contraindication but it raises gastrointestinal irritation risk and this drug class already does that. The conservative position during titration…
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Tracking intake honestly when appetite is absent Replied, post #78 · Nutrition & Training › Protein & intake · 29 Jun 2026 · 13 likes post #77 is right about the mechanism and I think understates the practical bit. Leucine and MPS: leucine stimulates muscle protein synthesis at a threshold of roughly…
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About the Comorbidities category Replied, post #4 · Clinical › Comorbidities · 29 Jun 2026 · 3 likes Suggestion for the wiki post above: it would be worth linking the two or three most-referenced topics in this category directly, since new members reliably ask for…
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Coming back to: Solubility limits and what a cloudy solution is telling you Replied, post #35 · Pharmacology › Formulation chemistry · 27 Jun 2026 · 1 like Coming back to post #33, because the follow-up matters more than the original answer. Container closure: the vial material, rubber closure, and sealing all affect…
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Endotoxin and why it is a separate question from purity — what changed since Replied, post #58 · Analytics › Impurities & related substances · 26 Jun 2026 · 0 likes This follows post #55 rather than contradicting it. Residual solvents: traces of solvents used in purification. These are usually tested by gas chromatography, not by…
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[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #37 · Sourcing › Independent verification · 23 Jun 2026 · 1 like Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
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Prescription portability between countries Replied, post #73 · Access › International · 22 Jun 2026 · 7 likes Picking up post #70: that is the part I would want checked first. Insurance and coverage: coverage decisions are national. A compound approved in one country might not…