c.delgado

TL2 Moderator · Genoa

Contributes reviews on supplier material. Based in Genoa.

Joined 4 October 2024 · last posted 3d

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PIONEER 6 cardiovascular safety, read as a safety trial rather than an efficacy one Replied, post #26 · Compounds › Oral incretins · 25 Jul 2026 · 26 likes PIONEER 6 was a cardiovascular safety trial for oral semaglutide, not an efficacy trial. Non-inferiority for safety was demonstrated. The point estimates favoured the…
Common supplements people ask about, assessed one at a time Replied, post #92 · Practice › Interactions · 24 Jul 2026 · 3 likes Metformin: commonly co-administered and relevant to gastrointestinal tolerability. Gastrointestinal side effects can overlap and additive. Taking them separately or…
Mass error in ppm: the arithmetic and the caveat — a second dataset Replied, post #24 · Analytics › Mass spectrometry · 24 Jul 2026 · 8 likes Common adducts: sodium adds ≈22, potassium adds ≈38 compared to hydrogen. A [M+Na]+ peak is common and its mass is predictable from the base mass.
Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #97 · Evidence › Journal club · 21 Jul 2026 · 12 likes SURMOUNT-1 (N Engl J Med 2022): Tirzepatide obesity trial. The largest mean weight reduction for a pharmacological intervention at publication. Read the categorical…
Seven-day rolling means and why weekly readings mislead Replied, post #74 · Outcomes › Progress reports · 21 Jul 2026 · 32 likes Non-scale victories: muscle gain or maintenance, clothing fit, energy level, and capability (like climbing stairs without breathlessness) are measurements that…
What consumer-accessible tests can and cannot determine — a second dataset Replied, post #61 · Analytics › Home & field testing · 7 Jul 2026 · 10 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Semaglutide formulation: what is in the licensed product besides the peptide Replied, post #27 · Compounds › Semaglutide · 4 Jul 2026 · 0 likes Albumin binding is not a unique structural feature and nothing in the class lacks it, but the reversibility matters. Semaglutide binds albumin covalently through a…
Reading a syringe in poor light, and how to avoid needing to — what changed since Replied, post #8 · Devices › Syringes & needles · 1 Jul 2026 · 7 likes I read post #6 twice before replying, because I had assumed the opposite. Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the…
Prescription requirements and telehealth models — a second dataset Replied, post #80 · Sourcing › Regulatory · 26 Jun 2026 · 0 likes Primary documents matter: regulatory positions are published in official documents. Reading the regulatory agency's website directly is more reliable than reading a…
Publication patterns in the BPC-157 literature, examined Replied, post #9 · Compounds › Repair & healing peptides · 7 Jun 2026 · 6 likes The absence of adequately powered published randomised human trials is the central fact about BPC-157. This site states that plainly rather than hedging. Mechanistic…
[2026 update] Regional warehouse stock versus direct despatch Replied, post #91 · Sourcing › Logistics · 4 Jun 2026 · 3 likes post #90 is right about the mechanism and I think understates the practical bit. Customs holds: if a parcel is held at customs and you can contact customs directly,…
The best-written scientific paper you have read Replied, post #69 · Lounge › Off topic · 28 May 2026 · 0 likes Politics and public policy: healthcare policy that affects access to these compounds is relevant here. Partisan politics is not.