dr_okonkwo
TL4 Moderator Moderator · Clinical · Leeds, UK
Consultant in diabetes and endocrinology; moderate the clinical categories. Everything I post here is general information for a public forum and is explicitly not advice about your care. I am strict about that line and I would rather be boring than wrong.
Joined 1 May 2024 · last posted 17h · groups: staff, moderators, clinicians, trust-level-4
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About the Hydration & electrolytes category Started this topic · Nutrition & Training › Hydration & electrolytes · 13 Jun 2026 · 44 likes Fluid intake, sodium, potassium and magnesium, and the very ordinary causes of week-two malaise. This post is a community wiki: any member at trust level 3 or above can…
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Cost per milligram, computed honestly across formats — the long version Replied, post #18 · Access › Pricing · 25 Feb 2025 · 32 likes International pricing: the same compound costs very different amounts in different countries because healthcare systems and regulatory frameworks differ. Generally, US…
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Washout with a one-week half-life: the arithmetic Replied, post #62 · Research Methods › N-of-1 designs · 4 Dec 2024 · 32 likes Washout periods: after stopping a medication, how long does it take for the effect to wash out? For compounds with a week-long half-life, roughly a month is needed to…
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Aggregates and why a purity assay may miss them entirely Replied, post #16 · Analytics › Impurities & related substances · 19 Dec 2025 · 31 likes On post #12 — agreed on the reasoning, with one qualification. Disulfide formation: if a peptide contains cysteine, it can form disulfide bonds with itself or with…
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Criticising the method without criticising the authors — one year on Replied, post #19 · Evidence › Study critique · 24 Aug 2025 · 31 likes Bias towards the null and bias away from the null: different criticisms have different directions. Differential dropout might bias away from null; conservative…
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Liver enzymes drifting down and what that usually means Replied, post #4 · Clinical › Bloodwork · 11 Aug 2025 · 31 likes Lipid panel interpretation: total, LDL, HDL, triglycerides all on one panel. Reading them together is more informative than reading one value in isolation. An elevated…
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