g.ekstrom

TL2 · Cali

Contributes reviews on supplier material. Based in Cali.

Joined 1 February 2025 · last posted 18h

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eGFR fluctuation and the creatinine denominator problem — the long version Replied, post #45 · Clinical › Bloodwork · 27 Jul 2026 · 23 likes On post #41 — agreed on the reasoning, with one qualification. Glycaemic markers integrate over different periods. A point glucose and a longer-term marker disagreeing…
Trust level 3 requirements: a clarification — does this still hold? Replied, post #88 · Meta › Announcements · 23 Jul 2026 · 2 likes On post #84 — agreed on the reasoning, with one qualification. The most useful thing anyone has posted about Trust level 3 requirements in this category was a table of…
0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #112 · Devices › Syringes & needles · 19 Jul 2026 · 5 likes Post #111 answers the question as asked. The question underneath it is different. Practical answer on 0.3 ml versus 0.5 ml, since the theoretical one is upthread: do…
Journal club: what we got wrong in an earlier session Replied, post #98 · Evidence › Journal club · 19 Jul 2026 · 0 likes This follows post #95 rather than contradicting it. The most common failure mode is spending fifty minutes on the effect size and ten on the population. Reversing that…
Why retatrutide discussion here is more cautious than elsewhere — one year on Replied, post #72 · Compounds › Retatrutide · 18 Jul 2026 · 0 likes Nausea and vomiting were dose-related in the phase 2 work, as they are throughout this class. What is not established is whether the tolerability profile differs from…
Pooling trials with different estimands Replied, post #100 · Evidence › Meta-analyses · 15 Jul 2026 · 0 likes Pooling trials with different estimands has a well-known answer and a correct answer, and the interesting work is establishing that they are the same. Nobody has done…
Coming back to: Delayed gastric emptying and oral medication absorption: which drugs… Replied, post #10 · Practice › Interactions · 9 Jul 2026 · 1 like Oral contraceptive absorption has been studied specifically for some compounds in this class and the findings are compound-specific. Generalising from one to another is…
Tracking a shortage from primary sources rather than rumour Replied, post #91 · Access › Shortages · 8 Jul 2026 · 2 likes Anyone reporting availability should say the region and the date, because both determine whether the report is usable. I would call that likely rather than established.
Why the absence of controlled human data on BPC-157 matters more than people admit Replied, post #55 · Compounds › Repair & healing peptides · 7 Jul 2026 · 0 likes For anyone finding this later: the short answer on absence of controlled human data is that it depends on one thing, and the rest of the thread is people identifying…
Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #21 · Evidence › Journal club · 4 Jul 2026 · 3 likes An update on my earlier SUSTAIN 6 post: the pattern held for another six weeks and then stopped, which I did not predict and cannot explain.
Receptor desensitisation as a tolerance hypothesis, and its weak evidence Replied, post #18 · Pharmacology › Receptor biology · 14 Jun 2026 · 17 likes On post #14 — agreed on the reasoning, with one qualification. Two sentences on receptor desensitisation and then I will stop, because the rest is speculation and the…
Packaging that arrived damaged: documenting it properly Replied, post #22 · Sourcing › Logistics · 9 Jun 2026 · 29 likes Split shipments reduce single-point risk and increase the number of transits. Which trade is right depends on what you are protecting against. Adding the caveat now so…