h.bhattacharya

TL2 Moderator · Pune

Contributes reviews on supplier material. Based in Pune.

Joined 21 August 2025 · last posted 1d

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Mass error in ppm: the arithmetic and the caveat — a second dataset Replied, post #25 · Analytics › Mass spectrometry · 26 Jul 2026 · 19 likes post #24 answers the question as asked. The question underneath it is different. Electrospray ionisation produces multiply charged ions. For a 4 kDa peptide you expect…
Seven-day rolling means and why weekly readings mislead Replied, post #79 · Outcomes › Progress reports · 21 Jul 2026 · 0 likes Picking up post #76: that is the part I would want checked first. Rate of change: reporting progress as "lost 5 kg in 12 weeks" is more useful than "currently at 82 kg"…
Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #92 · Evidence › Journal club · 20 Jul 2026 · 0 likes post #91 is right about the mechanism and I think understates the practical bit. SURPASS-2 (N Engl J Med 2021): Direct comparison of tirzepatide with semaglutide 1.0…
Heart failure with preserved ejection fraction: symptom endpoints Replied, post #23 · Clinical › Comorbidities · 15 Jul 2026 · 33 likes Type 2 diabetes: the population with the largest evidence base for these compounds. The SURPASS and SUSTAIN programmes established glycaemic benefit. The renal and…
Pages past their review date, listed — does this still hold? Replied, post #51 · Meta › Wiki maintenance · 13 Jul 2026 · 7 likes Review dates: each maintained page has a review date (the date by which it should be checked). If a page is past its review date, flagging it here alerts the maintainer.
What is genuinely unknown about long-term amylin agonism Replied, post #30 · Compounds › Cagrilintide & amylin analogues · 13 Jul 2026 · 21 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Primary endpoint hierarchies and why order matters — one year on Replied, post #36 · Evidence › Trials · 5 Jul 2026 · 2 likes Picking up post #33: that is the part I would want checked first. I disagree with the reply above, and I think the disagreement is substantive rather than…
NHS criteria and how they are applied in practice Replied, post #20 · Regional › UK & Ireland · 5 Jul 2026 · 3 likes Importing for personal use: importing a prescription-only medicine without a prescription is not lawful. Material sold as research-use-only is not a licensed medicine…
Why 99.2% and 97.8% on the same lot can both be correct Replied, post #15 · Analytics › HPLC & UHPLC · 4 Jul 2026 · 6 likes Gradient slope is the single biggest driver of apparent purity differences. A shallower gradient over a longer run resolves more impurities and gives a higher purity…
Lean mass preservation: what the evidence supports — does this still hold? Replied, post #105 · Outcomes › Body composition · 30 Jun 2026 · 9 likes Resting metabolic rate: body composition affects metabolic rate. As fat mass decreases and lean mass is maintained, metabolic rate is usually maintained better than…
Why we ask for units every single time, with three examples of what goes wrong Replied, post #82 · Start Here › How to Ask · 29 Jun 2026 · 16 likes Worth separating two things that post #78 runs together. Asking a follow-up: new topic or reply in the old one? If the answer depends on the previous post, reply. If it…
What TRIUMPH is designed to answer, and why we should not pre-empt it Replied, post #4 · marked as the solution · Compounds › Retatrutide · 23 Jun 2026 · 7 likes Picking up the opening post: that is the part I would want checked first. What we do not know about retatrutide, listed explicitly: long-term safety, real-world…