l.pires

TL2 Moderator · Aarhus

Contributes reviews on supplier material. Based in Aarhus.

Joined 19 February 2025 · last posted 3d · groups: regional-na

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Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #95 · Practice › Dosing & titration · 25 Jul 2026 · 4 likes Reaching a dose and staying there for a year: the question of whether a stable dose remains effective over years is mostly answered by the withdrawal trials and by…
What the GIP component of tirzepatide is thought to contribute, and how confident we can… Replied, post #13 · Compounds › Tirzepatide · 21 Jul 2026 · 0 likes This follows post #10 rather than contradicting it. Titration schedules for tirzepatide have more dose steps than semaglutide partly because the compound is more potent…
Which categories are strict and which are relaxed, honestly Replied, post #24 · Start Here › Welcome · 17 Jul 2026 · 2 likes Picking up post #21: that is the part I would want checked first. The moderation log is public. Every staff action is logged with the rule cited and the reasoning…
Common supplements people ask about, assessed one at a time Replied, post #56 · Practice › Interactions · 16 Jul 2026 · 25 likes Vitamins: most vitamins have no significant interaction. Fat-soluble vitamins (A, D, E, K) might be affected by the slowing of fat absorption during weight loss, but…
Blinding yourself: practical methods and their limits — the long version Replied, post #10 · Research Methods › N-of-1 designs · 16 Jul 2026 · 18 likes Statistical analysis of n-of-1 data: comparing before versus after with a t-test or similar is one approach. Plotting the data visually is another. Both are valid.
Prior authorisation: what the criteria usually require — a second dataset Replied, post #32 · Access › Insurance & coverage · 15 Jul 2026 · 3 likes post #31 answers the question as asked. The question underneath it is different. Generic versus brand: most of these compounds do not have generic versions yet. Once…
What consumer-accessible tests can and cannot determine — a second dataset Replied, post #82 · Analytics › Home & field testing · 13 Jul 2026 · 0 likes This follows post #79 rather than contradicting it. Immunoassay limitations: tests that use antibodies have cross-reactivity limitations. An antibody raised to…
Coming back to: Delayed gastric emptying and oral medication absorption: which drugs… Replied, post #15 · Practice › Interactions · 11 Jul 2026 · 8 likes post #14 answers the question as asked. The question underneath it is different. Food interactions: most interactions are absorption interactions. Some medications…
Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #38 · Evidence › Journal club · 8 Jul 2026 · 15 likes SURMOUNT-OSA (N Engl J Med 2024): Tirzepatide in obstructive sleep apnoea, using an objective physiological endpoint. Notable because soft endpoints are avoided. Two…
A structured critique template this community uses — a second dataset Replied, post #30 · Evidence › Study critique · 6 Jul 2026 · 4 likes On post #26 — agreed on the reasoning, with one qualification. Generalisability: do the inclusion/exclusion criteria narrow the population so much that results do not…
Tracking a shortage from primary sources rather than rumour Replied, post #84 · Access › Shortages · 4 Jul 2026 · 9 likes This follows post #81 rather than contradicting it. Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still…
Alcohol: what is documented and what is folklore Replied, post #84 · Practice › Interactions · 30 Jun 2026 · 0 likes Metformin: commonly co-administered and relevant to gastrointestinal tolerability. Gastrointestinal side effects can overlap and additive. Taking them separately or…