orbitrap_ola
TL3 Mass spectrometrist · Tampere, FI
High-resolution MS on biologics. Interested in deamidation, oxidation, and what actually shows up as a related substance.
Joined 24 December 2024 · last posted 14h · groups: analytical-chemists, newcomer-guides
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Talking to a therapist about this specifically Replied, post #25 · Wellbeing › Mental health · 27 Jul 2026 · 2 likes Picking up post #22: that is the part I would want checked first. Social and relationship impacts: weight change affects how others perceive and interact with a person.…
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Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #118 · Evidence › Journal club · 26 Jul 2026 · 0 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
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Coming back to: Delayed gastric emptying and oral medication absorption: which drugs… Replied, post #60 · Practice › Interactions · 23 Jul 2026 · 0 likes Separation timing versus clinically important interaction: a separation timing inconvenience (taking one medication 2 hours before or after another) is not the same as…
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Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #115 · Compounds › Semaglutide · 21 Jul 2026 · 3 likes The mass figure differs between sources because of how the different entities report it. The monoisotopic mass of the bare peptide is one number; the mass including the…
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[2026 update] Antibiotics and a course of something with delayed emptying Replied, post #68 · Practice › Interactions · 20 Jul 2026 · 0 likes Sulfonylureas and meglitinides: these agents stimulate insulin release and carry hypoglycemia risk. Combining them with semaglutide or tirzepatide requires dose…
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Pooling trials with different estimands Replied, post #113 · Evidence › Meta-analyses · 20 Jul 2026 · 0 likes Picking up post #110: that is the part I would want checked first. Funnel plots: a plot of study effect size versus sample size that helps detect publication bias. If…
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A 5 mg vial and a 0.25 mg dose: the arithmetic in full Replied, post #132 · Practice › Reconstitution · 19 Jul 2026 · 7 likes Choosing a concentration on purpose rather than by accident: starting with "I want to draw 0.5 mL per dose" and working backward to the required concentration is more…
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Molecular mass of semaglutide and why the figure differs between sources Replied, post #102 · Compounds › Semaglutide · 16 Jul 2026 · 2 likes I read post #100 twice before replying, because I had assumed the opposite. The 165 to 184 hour range: that is roughly 7 to 7.6 days, which is why the weekly schedule…
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Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #81 · Analytics › Impurities & related substances · 16 Jul 2026 · 33 likes On post #77 — agreed on the reasoning, with one qualification. Deletion sequences (incomplete coupling during synthesis): lower in mass by one residue.…
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Receptor desensitisation as a tolerance hypothesis, and its weak evidence Replied, post #44 · Pharmacology › Receptor biology · 14 Jul 2026 · 2 likes GIP receptor signalling: the glucose-dependent insulinotropic peptide receptor (GIP) is involved in glucose-stimulated insulin secretion. GIP agonism is thought to…
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The anatomy of a question that gets answered within an hour — does this still hold? Replied, post #21 · Start Here › How to Ask · 13 Jul 2026 · 2 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
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Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #49 · Evidence › Journal club · 11 Jul 2026 · 0 likes Picking up post #46: that is the part I would want checked first. SELECT (N Engl J Med 2023): Semaglutide cardiovascular outcomes without diabetes. The first outcome…
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- LC-MS identity confirmationReview due 23 Mar 2027