s.grahame
TL2 Member · Quebec City, CA
Practical questions, practical answers. Not interested in speculation without a source.
Joined 14 December 2024 · last posted 3d
83Posts here
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Coming back to: A structured critique template this community uses Replied, post #68 · Evidence › Study critique · 25 Jul 2026 · 7 likes On post #64 — agreed on the reasoning, with one qualification. Per-protocol and intention-to-treat analyses answer different questions and neither is the honest one by…
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What a reversed-phase purity number actually is Replied, post #81 · Analytics › HPLC & UHPLC · 22 Jul 2026 · 2 likes Counterpoint on reversed-phase purity number, offered without confidence: the same observation is consistent with a much duller explanation, and nobody has ruled the…
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Here for the analytics and not much else Replied, post #55 · Lounge › Introductions · 19 Jul 2026 · 6 likes Privacy: share only what you are comfortable making permanent and public. An introduction is archived and searchable; do not include information you will later regret…
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[2026 update] Travelling with an injectable: documentation and practicalities Replied, post #88 · Access › International · 17 Jul 2026 · 7 likes Where a compound is approved under a different trade name in another market, searching the local name finds documents the English name does not.
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What a reversed-phase purity number actually is Replied, post #62 · Analytics › HPLC & UHPLC · 17 Jul 2026 · 0 likes A relative retention time against a known peak travels much better than an absolute one, and almost nobody reports it. Small point, but it is the one that usually…
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Coming back to: Lateral-flow and colorimetric approaches: the specificity problem Replied, post #76 · Analytics › Home & field testing · 14 Jul 2026 · 5 likes Whatever the answer on Lateral-flow and colorimetric approaches turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in…
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A supplier who responds to a discrepancy with silence — what changed since Replied, post #80 · Sourcing › Red flags · 13 Jul 2026 · 31 likes Posting my supplier numbers with the method attached so they can be discounted properly. Uncontrolled, unblinded, and collected by someone who wanted a particular answer.
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Aggregate verification data across the directory, with caveats Replied, post #43 · Sourcing › Independent verification · 12 Jul 2026 · 23 likes The thing about aggregate verification data that took me longest to accept is that a plausible mechanism is not evidence of an effect. It is a reason to look, not a…
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Revisiting: Liver enzymes drifting down and what that usually means Replied, post #49 · Clinical › Bloodwork · 27 Jun 2026 · 0 likes Picking up post #46: that is the part I would want checked first. Liver enzymes drifting sits at the boundary between what this community can usefully discuss and what…
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Revisiting: What pooling buys you and what it destroys Replied, post #69 · Evidence › Meta-analyses · 26 Jun 2026 · 26 likes Nothing to add, except that this is the answer I would give if asked.
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[2026 update] Regional warehouse stock versus direct despatch Replied, post #101 · Sourcing › Logistics · 14 Jun 2026 · 1 like Tracking stops updating: tracking last updated days ago usually means the package is in transit and will not update until it reaches the next scanning point. No update…
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Batch numbers that do not match the vial label Replied, post #21 · Sourcing › Red flags · 27 May 2026 · 19 likes Practical experience of batch numbers, offered as one case with the conditions stated, not as a general finding. Conditions first, because they are what make it…